Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS.
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites. Nature 2022;603:907–912.
Harvey EP, Shin J-E, Skiba MA, Nemeth GR, Hurley JD, Wellner A, Shaw AY, Miranda VG, Min JK, Liu CC, Marks DS, Kruse AC.
An in silico method to assess antibody fragment polyreactivity [Internet]. Nat Commun 2022;13(1):7554.
Publisher's Version Boivin B, Roet KCD, Huang X, Karhohs KW, Rohban MH, Sandoe J, Wiskow O, Maeda R, Grantham A, Dornon MK, Shao J, Frost D, Baker D, Eggan K, Carpenter AE, Woolf CJ.
A multiparametric activity profiling platform for neuron disease phenotyping and drug screening [Internet]. Mol Biol Cell 2022;33(6):ar54.
Publisher's Version Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu T-M, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H.
Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion [Internet]. Proc Natl Acad Sci U S A 2022;119(9):e2117198119.
Publisher's Version Ji Z, Li H, Peterle D, Paulo JA, Ficarro SB, Wales TE, Marto JA, Gygi SP, Engen JR, Rapoport TA.
Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase [Internet]. Mol Cell 2022;82(3):570-584.
Publisher's Version Mills CE, Subramanian K, Hafner M, Niepel M, Gerosa L, Chung M, Victor C, Gaudio B, Yapp C, Nirmal AJ, Clark N, Sorger PK.
Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop [Internet]. Nat Commun 2022;13(1):6918.
Publisher's Version Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin Y-F, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen Q-D, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman J-A, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG, McBrayer SK.
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma [Internet]. Cancer Cell 2022;40(9):939-956.
Publisher's Version Coverdell TC, Abraham-Fan R-J, Wu C, Abbott SBG, Campbell JN.
Genetic encoding of an esophageal motor circuit [Internet]. Cell Rep 2022;39(11):110962.
Publisher's Version Jutzi JS, Marneth AE, Ciboddo M, Guerra-Moreno A, Jiménez-Santos MJ, Kosmidou A, Dressman JW, Liang H, Hamel R, Lozano P, Rumi E, Doench JG, Gotlib J, Krishnan A, Elf S, Al-Shahrour F, Mullally A.
Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs [Internet]. Blood 2022;140(11):1291-1304.
Publisher's Version Yang Y, Santos DM, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black KE, Spinney JJ, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager AM, Seither P, Herrmann FE, Medoff BD.
Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis. Am J Respir Cell Mol Biol 2022;67(1):36-49.
Yao L, D'Agostino GD, Park J, Hang S, Adhikari AA, Zhang Y, Li W, Avila-Pacheco J, Bae S, Clish CB, Franzosa EA, Huttenhower C, Huh JR, Devlin AS.
A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria. Nat Microbiol 2022;7(9):1404-1418.
Tharappel AM, Li Z, Zhu YC, Wu X, Chaturvedi S, Zhang QY, Li H.
Calcimycin Inhibits Cryptococcus neoformansIn Vitro and In Vivo by Targeting the Prp8 Intein Splicing. ACS Infect Dis 2022;8(9):1851-1868.
Kuiken HJ, Dhakal S, Selfors LM, Friend CM, Zhang T, Callari M, Schackmann RCJ, Gray GK, Crowdis J, Bhang HEC, Baslan T, Stegmeier F, Gygi SP, Caldas C, Brugge JS.
Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts. Oncogene 2022;41(1):112-124.
Muscato JD, Morris HG, Mychack A, Rajagopal M, Baidin V, Hesser AR, Lee W, İnecik K, Wilson LJ, Kraml CM, Meredith TC, Walker S.
Rapid Inhibitor Discovery by Exploiting Synthetic Lethality. J Am Chem Soc 2022;144(8):3696-3705.