Publications by Year: 2022

2022
Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS. Human gut bacteria produce ΤΗ17-modulating bile acid metabolites. Nature 2022;603:907–912.
Harvey EP, Shin J-E, Skiba MA, Nemeth GR, Hurley JD, Wellner A, Shaw AY, Miranda VG, Min JK, Liu CC, Marks DS, Kruse AC. An in silico method to assess antibody fragment polyreactivity [Internet]. Nat Commun 2022;13(1):7554. Publisher's Version
Boivin B, Roet KCD, Huang X, Karhohs KW, Rohban MH, Sandoe J, Wiskow O, Maeda R, Grantham A, Dornon MK, Shao J, Frost D, Baker D, Eggan K, Carpenter AE, Woolf CJ. A multiparametric activity profiling platform for neuron disease phenotyping and drug screening [Internet]. Mol Biol Cell 2022;33(6):ar54. Publisher's Version
Boekell KL, Brown BJ, Talbot BE, Schlondorff JS. Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets [Internet]. PLoS One 2022;17(6):e0270431. Publisher's Version
Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu T-M, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion [Internet]. Proc Natl Acad Sci U S A 2022;119(9):e2117198119. Publisher's Version
Ji Z, Li H, Peterle D, Paulo JA, Ficarro SB, Wales TE, Marto JA, Gygi SP, Engen JR, Rapoport TA. Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase [Internet]. Mol Cell 2022;82(3):570-584. Publisher's Version
Brown BJ, Boekell KL, Stotter BR, Talbot BE, Schlondorff JS. Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models [Internet]. PLoS One 2022;17(8):e0272313. Publisher's Version
Mills CE, Subramanian K, Hafner M, Niepel M, Gerosa L, Chung M, Victor C, Gaudio B, Yapp C, Nirmal AJ, Clark N, Sorger PK. Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop [Internet]. Nat Commun 2022;13(1):6918. Publisher's Version
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin Y-F, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen Q-D, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman J-A, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG, McBrayer SK. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma [Internet]. Cancer Cell 2022;40(9):939-956. Publisher's Version
Coverdell TC, Abraham-Fan R-J, Wu C, Abbott SBG, Campbell JN. Genetic encoding of an esophageal motor circuit [Internet]. Cell Rep 2022;39(11):110962. Publisher's Version
Jutzi JS, Marneth AE, Ciboddo M, Guerra-Moreno A, Jiménez-Santos MJ, Kosmidou A, Dressman JW, Liang H, Hamel R, Lozano P, Rumi E, Doench JG, Gotlib J, Krishnan A, Elf S, Al-Shahrour F, Mullally A. Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs [Internet]. Blood 2022;140(11):1291-1304. Publisher's Version
Yang Y, Santos DM, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black KE, Spinney JJ, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager AM, Seither P, Herrmann FE, Medoff BD. Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis. Am J Respir Cell Mol Biol 2022;67(1):36-49.
Li DK, Chaudhari SN, Lee Y, Sojoodi M, Adhikari AA, Zukerberg L, Shroff S, Barrett SC, Tanabe K, Chung RT, Devlin AS. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury. Sci Adv 2022;8(34)
Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman R-U, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Sui SJH, Doerner JF, Rippmann JF, Mullen AC. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife 2022;11(May 26)
Yao L, D'Agostino GD, Park J, Hang S, Adhikari AA, Zhang Y, Li W, Avila-Pacheco J, Bae S, Clish CB, Franzosa EA, Huttenhower C, Huh JR, Devlin AS. A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria. Nat Microbiol 2022;7(9):1404-1418.
Tharappel AM, Li Z, Zhu YC, Wu X, Chaturvedi S, Zhang QY, Li H. Calcimycin Inhibits Cryptococcus neoformansIn Vitro and In Vivo by Targeting the Prp8 Intein Splicing. ACS Infect Dis 2022;8(9):1851-1868.
Kuiken HJ, Dhakal S, Selfors LM, Friend CM, Zhang T, Callari M, Schackmann RCJ, Gray GK, Crowdis J, Bhang HEC, Baslan T, Stegmeier F, Gygi SP, Caldas C, Brugge JS. Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts. Oncogene 2022;41(1):112-124.
Muscato JD, Morris HG, Mychack A, Rajagopal M, Baidin V, Hesser AR, Lee W, İnecik K, Wilson LJ, Kraml CM, Meredith TC, Walker S. Rapid Inhibitor Discovery by Exploiting Synthetic Lethality. J Am Chem Soc 2022;144(8):3696-3705.
Strang BL. Toward inhibition of human cytomegalovirus replication with compounds targeting cellular proteins. J Gen Virol 2022;103(10)
Martínez-Noël G, Szajner P, Kramer RE, Boyland KA, Sheikh A, Smith JA, Howley PM. Identification of MicroRNAs That Stabilize p53 in Human Papillomavirus-Positive Cancer Cells. J Virol 2022;96(4)

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