Fee Summary

A fee is charged for access to ICCB-Longwood. This fee helps us to recover a portion of our operating expenses. ICCB-Longwood fees (and associated Facilities and Administration (F&A) fees) are revised annually based upon the Harvard Fiscal Year (July 1 – June 30). The fee structure is updated on the ICCB-Longwood website as soon as it is available. All charges are based on the fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below represent the rates for FY22 (July 1, 2021 - June 30, 2022).

The fees charged for access to ICCB-Longwood do not include the cost of screening reagents and supplies. Funding for all screening reagents and supplies is the responsibility of the screener.

Non-academic investigators should contact Jennifer Smith for the current industry price structure.

Small Molecule Screening Fees

Fees for HMS Internal Quad Screens

Screening Milestone
Fees 
Screen set-up fee $5,085
Additional fee for screening up to 5,000 experimental wells

$2,543

Additional fee for screening 5,001-10,000 experimental wells $2,119
Additional fee for screening 10,001-25,000 experimental wells $2,966
Additional fee for screening 25,001-50,000 experimental wells $4,238
Additional fee for screening 50,001-100,000 experimental wells $4,238
Fee for screening additional increments of 100,000 experimental wells $6,293

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Small Molecule Fees - HMS Affiliates and Non-Harvard Academic

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$5,085
$1,017
Additional fee for screening up to 5,000 experimental wells
$2,543
$509
Additional fee for screening 5,001-10,000 experimental wells
$2,119
$424
Additional fee for screening 10,001-25,000 experimental wells
$2,966
$594
Additional fee for screening 25,001-50,000 experimental wells
$4,238
$848
Additional fee for screening 50,001-100,000 experimental wells
$4,238
$848
Fee for screening additional increments of 100,000 experimental wells
$6,293
$1,259

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Functional Genomics Screening Fees

Fees for HMS Internal Quad Screens

Screening Milestone
Fees
Screen set-up fee
$5,085
Additional fee for screening full Synthego Druggable sgRNA CRISPR library (29 plates)
$7,076
Additional fee for screening one full genome siRNA library (66 plates)
$16,103
Per library plate fee

$244

Additional fee for screening lncRNA siRNA library

$1,708

Additional fee for screening each miRNA library $1,220
 Additional fee per library for screening: GPCR, Ion Channels, Proteases or Ubiquitin  $488
 Additional fee for screening Kinases $732

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $3 per duplex picked ($12 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Fees for HMS-Affiliated and Non-Harvard Academic Screens

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$5,085
$1,017
Additional fee for screening full Synthego Druggable sgRNA CRISPR library (29 plates)
$7,076
$1,416
Additional fee for screening one full genome siRNA library (66 plates)
$16,103
$3,221
Per library plate fee

$244

$49

Additional fee for screening lncRNA siRNA library

$1,708

$342

 Additional fee for screening each miRNA library $1,220  $244
 Additional fee per library for screening: GPCR, Ion Channels, Proteases or Ubiquitin $488  $98
 Additional fee for screening Kinases  $732  $147

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $3 per duplex picked ($12 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Instrument Training and Use Fees

Instrument Training

  • Investigators not conducting a small molecule or functional genomics screen can access ICCB-Longwood instrumentation. They are charged an initial training fee and subsequent independent use is charged hourly.
  • A training fee will be charged for each individual on each instrument they are trained.
  • HMS charges a Facilities and Administration (F&A) fee to HMS Affiliates and non-Harvard labs.

Training Fee

Instrument  Academic   Corresponding F&A 
High Content (IXM-C, IXM-C LZR, Acumen, iQue) $277 $55.40
Bravo (hourly) $110 $22
Other Instruments (except High Content and Bravo)  $130 $26

Instrument Use

  • Instrument use that is not part of an approved small molecule or functional genomics screen is charged hourly based on reserved and actual time used.   
  • PPMS is used for instrument reservations and calculates the time used.
  • HMS charges a Facilities and Administration (F&A) fee to HMS Affiliates and non-Harvard labs.

Hourly Use Charges

Instrument

 Hourly Rate Academic 

 Corresponding F&A 
Acumen
$16
$3.20
EnVision
$14
$2.80
FlexStation  $14 $2.80
HPD300
$10
$2.00
iQue
$38
$7.60
IXM-C and IXM-C LZR
$33
$6.60
Lumina II
$47
$9.40
qPCR
$10
$2.00
User Bravo
$47
$9.40

Annual Access

Instrument

 Academic 

 Corresponding F&A 
Combi
$250
$50
PlateLoc
$250
$50
Plate Washer  $250 $50

Custom Lab Automation Projects

Custom Lab Automation

  • Custom lab automation projects can be performed by ICCB-L team members.
  • Hourly time charged includes planning, consultation, and program calibration at ICCB-L, in addition to the actual automation.
  • HMS charges a Facilities and Administration (F&A) fee to HMS Affiliates and non-Harvard labs.
 
 Hourly Rate Academic 
 Corresponding F&A 
 Custom Lab Automation Projects 
$110
$22