Fee Summary

A fee is charged for access to ICCB-Longwood. This fee helps us to recover a portion of our operating expenses. ICCB-Longwood fees (and associated Facilities and Administration (F&A) fees) are revised annually based upon the Harvard Fiscal Year (July 1 – June 30). The fee structure is updated on the ICCB-Longwood website as soon as it is available. All charges are based on the fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below are for screening activities carried out in FY20 (July 1, 2019 – June 30, 2020).

The fees charged for access to ICCB-Longwood do not include the cost of screening reagents and supplies. Funding for all screening reagents and supplies is the responsibility of the screener.

Non-academic investigators should contact Jennifer Smith for the current industry price structure.

Small Molecule Screening Fees

Fees for HMS Internal Quad Screens

 

Screening Milestone
Fees 
Screen set-up fee $4,835
Additional fee for screening up to 5,000 experimental wells

$2,418

Additional fee for screening 5,001-10,000 experimental wells $2,015
Additional fee for screening 10,001-25,000 experimental wells $2,821
Additional fee for screening 25,001-50,000 experimental wells $4,029
Additional fee for screening 50,001-100,000 experimental wells $4,029
Fee for screening additional increments of 100,000 experimental wells $5,984

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $3 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Small Molecule Fees - HMS Affiliates and Non-Harvard Academic

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$4,835
$1,130
Additional fee for screening up to 5,000 experimental wells
$2,418
$565
Additional fee for screening 5,001-10,000 experimental wells
$2,015
$471
Additional fee for screening 10,001-25,000 experimental wells
$2,821
$659
Additional fee for screening 25,001-50,000 experimental wells
$4,029
$942
Additional fee for screening 50,001-100,000 experimental wells
$4,029
$942
Fee for screening additional increments of 100,000 experimental wells
$5,984
$2,591

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of theexperimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $3 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Functional Genomics Screening Fees

Fees for HMS Internal Quad Screens

Screening Milestone
Fees
Functional Genomics screen set-up fee
$4,534
Additional fee for screening full Synthego Druggable sgRNA CRISPR library
$6,670
Additional fee for screening one full genome siRNA library
$15,179
Additional fee for screening lncRNA siRNA library

$1,610

Additional fee for screening each miRNA reagent library

$1,150

In lieu of screening the full druggable sgRNA CRISPR library, it is possible to screen smaller, focused libraries:  
 Additional fee for screening: Kinases $920
In lieu of screening the full human genome siRNA library, it is possible to screen smaller, focused libraries:  
 Additional fee per library for screening: Phosphatases, Ubiquitin Conjugating Enzymes #1 or Ubiquitin Conjugating Enzymes #2 $230
 Additional fee per library for screening: G-protein Coupled Receptors, Ion Channels, Proteases or Ubiquitin Conjugating Enzymes #3  $460
 Additional fee for screening: Kinases $690

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $2 per duplex picked ($8 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Fees for HMS-Affiliated and Non-Harvard Academic Screens

Screening Milestone
Fees 
Corresponding F&A
RNAi screen set-up fee
$4,534
$1,083
Additional fee for screening full Synthego Druggable sgRNA CRISPR library
$6,670
$1,595
Additional fee for screening one full genome siRNA library
$15,179
$3,627
Additional fee for screening lncRNA siRNA library

$1,610

$385

Additional fee for screening each miRNA reagent library

$1,150

$275

IIn lieu of screening the full druggable sgRNA CRISPR library, it is possible to screen smaller, focused libraries:
 Additional fee per library for screening: Kinases $920  $220
In lieu of screening the full human genome library, it is possible to screen smaller, focused libraries:
 Additional fee per library for screening: Phosphatases, Ubiquitin Conjugating Enzymes #1 or Ubiquitin Conjugating Enzymes #2 $230  $55
 Additional fee per library for screening: G-protein Coupled Receptors, Ion Channels, Proteases or Ubiquitin Conjugating Enzymes #3 $460  $110
 Additional fee for screening: Kinases  $690  $165

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $2 per duplex picked ($8 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Instrument Training and Access Fees

Instrument Training and Access Fees

  • Investigators utilizing instrumentation at ICCB-Longwood and not conducting a small molecule or RNAi screen will be charged a fee for access.
  • A one-time training fee will be charged for each individual on each instrument they are trained.
  • For individuals originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard investigators), the F&A fee will be assessed at the time the fee is charged.  
  • In addition, there is a per-instrument annual access fee to help recover a portion of the costs associated with instrument maintenance.
  Fees for HMS Internal Quad Investigators Fees for HMS-Affiliated and Non-Harvard Academic Investigators
Instrument Training
$147
$147
Instrument Annual Access
$233
$233
F&A Fee  N/A $21

Custom Lab Automation Project Fees

Custom Lab Automation Fees

  • Custom lab automation projects can be performed by ICCB-L Staff as time allows.
  • Hourly time charged includes planning, consultation, and program calibration at ICCB-L, in addition to the actual automation.
  • For individuals from non-HMS Quad labs (including HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard screeners), the F&A will be assessed at the time the fee is charged.
 
Fees for HMS Internal Quad Investigators
Fees for HMS-Affiliated and Non-Harvard Academic Investigators
Custom Lab Automation Projects
$105/hour
$105/hour
F&A Fee
N/A
$19/hour

High Content Project

High Content Project Fees

  • There is an annual fee for High Content users that utilize the Acumen, iQue and/or ImageXpress Microscopes and use is not part of an ICCB-Longwood small molecule or RNAi screen.
  • Similar to other non-screening instrument use at ICCB-L, this fee is per instrument per user per year.
  • For individuals originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard investigators), the F&A fee will be assessed at the time the fee is charged. 
 
Fees for HMS Internal Quad Users
Fees for HMS-Affiliated and Non-Harvard Users
High Content Project
$700
$700
F&A Fee
N/A
$198