Fees

A fee is charged for access to Functional Genomics screening at ICCB-Longwood. This fee helps us to recover a portion of our operating expenses. ICCB-Longwood screening fees (and associated Facilities and Administration fees) are revised annually based on the Harvard Fiscal Year (July 1 – June 30). The fee structure is updated on the ICCB-Longwood website as soon as it is available. All charges are based on the screening fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below represent the current rates for FY22 (July 1, 2021 - June 30, 2022).

Note that fees charged for access to ICCB-Longwood do not include the cost of assay reagents and supplies. Funding for all assay reagents and supplies is provided by the screener.

Fees for HMS Internal Quad Screens

Screening Milestone
Fees
Screen set-up fee
$5,085
Additional fee for screening full Synthego Druggable sgRNA CRISPR library (29 plates)
$7,076
Additional fee for screening one full genome siRNA library (66 plates)
$16,103
Per library plate fee

$244

Additional fee for screening lncRNA siRNA library

$1,708

Additional fee for screening each miRNA library $1,220
 Additional fee per library for screening: GPCR, Ion Channels, Proteases or Ubiquitin  $488
 Additional fee for screening Kinases $732

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $3 per duplex picked ($12 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Fees for HMS-Affiliated and Non-Harvard Academic Screens

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$5,085
$1,017
Additional fee for screening full Synthego Druggable sgRNA CRISPR library (29 plates)
$7,076
$1,416
Additional fee for screening one full genome siRNA library (66 plates)
$16,103
$3,221
Per library plate fee

$244

$49

Additional fee for screening lncRNA siRNA library

$1,708

$342

 Additional fee for screening each miRNA library $1,220  $244
 Additional fee per library for screening: GPCR, Ion Channels, Proteases or Ubiquitin $488  $98
 Additional fee for screening Kinases  $732  $147

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $3 per duplex picked ($12 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Additional Information on Functional Genomics Fees

Fees will begin to be assessed once work is initiated at ICCB-Longwood. For screens originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and Non-Harvard investigators), the indicated F&A is added at each stage of the screening fee. The fee for screening Functional Genomics libraries will be assessed when the first library plate is screened.

The above fees for screening the full siRNA genome include cherry picks for the individual siRNA duplexes corresponding to 300 genes per screen (1200 duplexes for Dharmacon genome, 900 duplexes for an Ambion screen). Additional cherry picks can be requested at $3 per duplex picked ($12 per gene). Cherry picking will only be carried out for individual duplexes, not for SMARTpool reagents. Cherry picking can only be requested after primary screening of SMARTpool libraries. The duplex volume provided is the same volume of SMARTpool reagents that were used in the primary screen.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

It is possible for investigators to select whether they would like to screen the entire genome or instead screen focused siRNA libraries. For the human genome, this decision should be made prior to initiating the screen, as the most concise way to screen the entire genome is through utilizing the continuous human genome siRNA library. Custom siRNA library screening is also possible.

Interested investigators should contact Jennifer Smith for more details and/or to determine which rate applies to their screen.