De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, Buehler J, Stopka S, Regan M, Lin YF, Puliyappadamba V, Gao W, Khanal J, Evans L, Lee J, Guo L, Xiao Y, Xu M, Huang B, Jennings R, Bonal D, Martin-Sandoval M, Dang T, Gattie L, Cameron A, Lee S, Asara J, Kornblum H, Mak T, Looper R, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman M, Zacharias L, Mathews T, Losman JA, Richardson T, Cahill D, DeBerardinis R, Ligon K, Xu L, Ly P, Agar N, Abdullah K, Harris I, Kaelin W, McBrayer S. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.