Below is a list of publications that have resulted from RNAi screening efforts at ICCB-Longwood. Please notify us of your publications that involve use of the ICCB-Longwood Screening Facility.
Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J. Regulation of a distinct activated RIPK1 intermediatebridging complex I and complex II inTNFα-mediated apoptosis. PNAS 2018;115(26):E5944-E5953.
Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE. Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nat Genet. 2018;Jan 29 doi: 10.1038/s41588-018-0044-9.
Fu B, Zhao M, Wang L, Patil G, Smith JA, Juncadella IJ, Zuvela-Jelaska L, Dorf ME, Li S. RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling. Sci Rep 2017;Jun 2; 7(1):2683.
Simpson KJ, Smith JA. Knocking down the obstacles to functional genomics data sharing. Sci Data 2017;4:170019 doi:10.1038/sdata.2017.19.
Nelms B, Dalomba NF, Lencer W. A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis. J Cell Biol 2017;216(2):511-525.
Polachek WS, Moshrif HF, Franti M, Coen DM, Streenu VB, Strang BL. High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions. J Virol 2016;90(18):8360-71.
Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trinucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL. Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell Reports 2016;16(1):232-46.
Dutta B, Azhir A, Merino L-H, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Beuhler E, Fraser LDC. An interactive web-based application for Comprehensive Analysis of RNAi-screen Data. Nat Commun 2016;7:10578.
Lu R, Herrera BB, Eshleman HD, Fu Y, Bloom A, Li Z, Sacks DB, Goldberg MB. Shigella effector OspB activates mTORC1 in a manner that depends on IQGAP1 and promotes cell proliferation [Internet]. 2015; PLoS Pathog. Oct 16;11(10).
Perreira JM, Aker AM, Savidis G, Chin CR, McDougall WM, Portman JM, Meraner P, Smith MC, Rahman M, Baker RE, Gauthier A, Franti M, Brass AL. RNASEK is a V-ATPase-Associated factor required for endocytosis and the replication of rhinovirus, influenza A virus, and Dengue Virus [Internet]. 2015; Cell Rep. Jul 22. pii:S2211-1247(15)00726-3.
Papageorgiou A, Rapley J, Mesirov JP, Tamayo P, Avruch J. A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation [Internet]. 2015; PLoS One Mar 19;10(3):e0116096.
Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, Frazier M, Samson O, Wong KK, Kim C, Camargo FD. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway [Internet]. 2014; Nat Cell Biol Jan;16(1):108-17.
Mohr SE, Smith JA, Shamu CE, Neumuller RA, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches [Internet]. 2014; Nat Reviews. Sept (15):591-600.
Lee AS, Burdeinick-Kerr R, Whelan SP. A genome-wide siRNA screen identifies host factors required for vesicular stomatitis virus infection [Internet]. 2014; J Virol. Aug 1;88(15):8355-8360.
Johnston SJ, Shamu SE, Smith JA. Automation considerations for RNAi library formatting and high throughput transfection [Internet]. 2014; Frontiers in RNAi. eBook, eISBN:978-1-60805-940-9. Chapter 2 Pages 21-39.
Grayson AR, Walsh EM, Cameron MJ, Godec J, Ashworth T, Ambrose JM, Aserlind AB, Wang H, Evan GI, Kluk MJ, Bradner JE, Aster JC, French CA. MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma [Internet]. 2014; Oncogene, 2014 Mar 27;33(13):1736-42.
Yilmazel B, Hu Y, Sigoillot F, Smith JA, Shamu CE, Perrimon N, Mohr SE. Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics 2014;Jun 17;(15):192.
Ganem NJ, Cornils H, Chiu SY, O’Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation [Internet]. 2014; Cell 158, 833-48.
Tata A, Stoppel DC, Hong S, Ben-Zvi A, Xie T, Gu C. An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling [Internet]. J Cell Biol 2014;May 26;205(4):573-90. J Cell Biol. May 26;205(4):573-590.
Schmidt EE, Bano MS, Smith JA, Birmingham A, Boutros M, Shamu CE. Public repositories for RNAi screening data [Internet]. 2014; Frontiers in RNAi. eBook; eISBN:978-1-60805-940-9 Chapter 3 Pages 40-57.
Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth [Internet]. 2014; Cell host & microbe 15, 113-24.
Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell 2013;24(2):182-96.
Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach [Internet]. 2013; Nat Immunol Feb;14(2):179-85.
Fusco DN, Brisac C, John SP, Huang YW, Chin CR, Xie T, Zhao H, Zhang L, Chevalier S, Wambua D, Lin W, Peng L, Chung RT, Brass AL. A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication. Gastroenterology 2013;Jun; 144(7):1438-49.
Caradonna KL, Engel JC, Jacobi D, Lee CH, Burleigh BA. Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe 2013;Jan 16;13(1):108-17.
Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature 2013;Jul 11; 499(7457):238-42.
Zhao H, Lin W, Kumthip K, Cheng D, Fusco DN, Hofmann O, Jilg N, Tai AW, Goto K, Zhang L, Hide W, Jang JY, Peng LF, Chung RT. A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus. J Hepatol 2012;56(2):326-33.
Zhang X, Bedigian AV, Wang W, Eggert US. G protein-coupled receptors participate in cytokinesis [Internet]. 2012; Cytoskeleton (Hoboken, N.J.) 69, 810-8.
Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. 2012;Feb 19; 9(4):363-6.
Papageorgiou A, Avruch J. A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation. Methods Mol Biol 2012;821:187-214.
