Small Molecule Publications
Acknowledging ICCB-L in Publications
Researchers using the services of ICCB-L staff or equipment agree to acknowledge the support of 'ICCB-Longwood Screening Facility at Harvard Medical School' in publications arising from your use of the facility. If an ICCB-L member has made an important intellectual contribution to the project, as determined by generally accepted criteria for academic collaborations, then that person should be considered for authorship on the publication. If your project was supported by a grant that also directly supports the ICCB-L, please consult the ICCB-L Director regarding the appropriate grant citation. Please notify Jen Smith upon public release of your publication.
Below is a list of publications that have resulted from small molecule screening efforts at ICCB-Longwood. Please notify us of your publications that involve use of the ICCB-Longwood Screening Facility.
2016
Li J, Shin S, Sun, Yoon SO, Li C, Zhang E, Yu, Zhang J, Blenis. mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.
Cancer Res. 2016;76(16):4816–4827.
Li J, Shin S, Sun, Yoon SO, Li C, Zhang E, Yu, Zhang J, Blenis. mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.
Cancer Res. 2016;76(16):4816–4827.
2015
Chiaraviglio, Kirby J. High-throughput intracellular antimicrobial susceptibility testing of Legionella pneumophila.
Antimicrob Agents Chemother. . 2015;59(12):7517–29.
Chiaraviglio, Kirby J. High-throughput intracellular antimicrobial susceptibility testing of Legionella pneumophila.
Antimicrob Agents Chemother. . 2015;59(12):7517–29.
Park C, Zhou E, Tambe, Chen, Lavoie, Dowell, Simeonov, Maloney D, Marinkovic, Tschumperlin D, Burger, Frykenberg, Butler J, Stamer W, Johnson, Solway, Fredberg J, Krishnan. High-throughput screening for modulators of cellular contractile force.
Integr Biol (Camb). 2015;7(10):1318–24.
Park C, Zhou E, Tambe, Chen, Lavoie, Dowell, Simeonov, Maloney D, Marinkovic, Tschumperlin D, Burger, Frykenberg, Butler J, Stamer W, Johnson, Solway, Fredberg J, Krishnan. High-throughput screening for modulators of cellular contractile force.
Integr Biol (Camb). 2015;7(10):1318–24.
Pery, Sheehy, Nebane M, Misra, Mankowski M, Rasmussen, White L, Ptak R, Gabuzda. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1.
Virology. 2015;484:276–87.
Pery, Sheehy, Nebane M, Misra, Mankowski M, Rasmussen, White L, Ptak R, Gabuzda. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1.
Virology. 2015;484:276–87.
Radomska H, Jernigan, Nakayama, Jorge S, Sun, Tenen D, Kobayashi S. A Cell-Based High-Throughput Screening for Inducers or Myeloid Differentiation.
J Biomol Screen. 2015;20(9):1150–9.
Radomska H, Jernigan, Nakayama, Jorge S, Sun, Tenen D, Kobayashi S. A Cell-Based High-Throughput Screening for Inducers or Myeloid Differentiation.
J Biomol Screen. 2015;20(9):1150–9.
Friedman A, Amzallag, Pruteanu-Malinici, Baniya, Cooper Z, Piris, Hargreaves, Igras, Frederick J, Lawrence D, Haber D, Flaherty K, Wargo J, Ramaswamy, Benes C, Fisher D. Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEFR/PDGFR Combination Treatment.
PLoS One. 2015;10(10):0140310.
Friedman A, Amzallag, Pruteanu-Malinici, Baniya, Cooper Z, Piris, Hargreaves, Igras, Frederick J, Lawrence D, Haber D, Flaherty K, Wargo J, Ramaswamy, Benes C, Fisher D. Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEFR/PDGFR Combination Treatment.
PLoS One. 2015;10(10):0140310.
Wallace, Bowlin N, Mills D, Saenkham, Kwasny S, Opperman T, Williams D, Rock C, Bowlin T, Moir D. Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay.
Antimicrob Agents Chemother. 2015;59(9):5775–87.
Wallace, Bowlin N, Mills D, Saenkham, Kwasny S, Opperman T, Williams D, Rock C, Bowlin T, Moir D. Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay.
Antimicrob Agents Chemother. 2015;59(9):5775–87.
Crowther G, Weller S, Jones J, Weaver, Fan, Voorhis WV, Rosen. The Bacterial Sec Pathway of Protein Export: Screening and Follow-Up.
J Biomol Screen. 2015;20(7):921–6.
Crowther G, Weller S, Jones J, Weaver, Fan, Voorhis WV, Rosen. The Bacterial Sec Pathway of Protein Export: Screening and Follow-Up.
J Biomol Screen. 2015;20(7):921–6.
Johnson B, Colvin C, Needle D, Medie M, Champion P, Abramovitch R. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.
Antimicrob Agents Chemother. 2015;59(8):4436–45.
Johnson B, Colvin C, Needle D, Medie M, Champion P, Abramovitch R. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.
Antimicrob Agents Chemother. 2015;59(8):4436–45.
RNA Biol. 2015;12(8):792–800.
RNA Biol. 2015;12(8):792–800.
Kim W, Conery A, Rajamuthiah, Fuchs B, Ausubel F, Mylonakis E. Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.
PLoS One. 2015;10(6):e0127640.
Kim W, Conery A, Rajamuthiah, Fuchs B, Ausubel F, Mylonakis E. Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.
PLoS One. 2015;10(6):e0127640.
Wei, Kozono, Kats, Nechama, Li, Guarnerio, Luo, You M, Yao, Kondo, Hu, Bozkurt, Moerke N, Cao, Reschke, Chen C, Rego E, Lo-Coco, Cantley L, Lee T, Wu, Zhang Y, Pandolfi P, Zhou X, Lu K. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Nat Med. 2015;21(5):457–66.
Wei, Kozono, Kats, Nechama, Li, Guarnerio, Luo, You M, Yao, Kondo, Hu, Bozkurt, Moerke N, Cao, Reschke, Chen C, Rego E, Lo-Coco, Cantley L, Lee T, Wu, Zhang Y, Pandolfi P, Zhou X, Lu K. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Nat Med. 2015;21(5):457–66.
Yi, Arthanari, Akabayov, Song, Papadopoulos, Qi H, Jedrychowski, Guttler, Guo C, Luna R, Gygi S, Huang S, Wagner G. elF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference.
Nat Commun. 2015;6:7194.
Yi, Arthanari, Akabayov, Song, Papadopoulos, Qi H, Jedrychowski, Guttler, Guo C, Luna R, Gygi S, Huang S, Wagner G. elF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference.
Nat Commun. 2015;6:7194.
Pery, Sheehy, Nebane N, Brazier A, Misra, Rajendran K, Buhrlage S, Mankowski M, Rasmussen, White E, Ptak R, Gabuzda. Identification of novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.
J Biol Chem. 2015;290(16):10504–17.
Pery, Sheehy, Nebane N, Brazier A, Misra, Rajendran K, Buhrlage S, Mankowski M, Rasmussen, White E, Ptak R, Gabuzda. Identification of novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.
J Biol Chem. 2015;290(16):10504–17.
Landeta, Blazyk J, Hatahet, Meehan B, Eser, Myrick A, Bronstain, Minami, Arnold, Ke, Rubin E, Furie B, Furie, Beckwith J, Dutton, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria.
Nat Chem Biol. 2015;11(4):292–8.
Landeta, Blazyk J, Hatahet, Meehan B, Eser, Myrick A, Bronstain, Minami, Arnold, Ke, Rubin E, Furie B, Furie, Beckwith J, Dutton, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria.
Nat Chem Biol. 2015;11(4):292–8.
Carocci, Hinshaw S, Rodgers M, Villareal V, Burri D, Pilankatta, Maharaj N, Gack M, Stavale E, Warfield K, Yang P. The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication.
Antimicrob Agents Chemother. 2015;59(1):85–95.
Carocci, Hinshaw S, Rodgers M, Villareal V, Burri D, Pilankatta, Maharaj N, Gack M, Stavale E, Warfield K, Yang P. The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication.
Antimicrob Agents Chemother. 2015;59(1):85–95.
Medvetz, Sun, Li C, Khabibulin, Balan, Parkhitko, Priolo, Asara J, Pal S, Yu, Henske E. High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.
Mol Cancer Res. 2015;13(1):50–62.
Medvetz, Sun, Li C, Khabibulin, Balan, Parkhitko, Priolo, Asara J, Pal S, Yu, Henske E. High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.
Mol Cancer Res. 2015;13(1):50–62.
Fallahi-Sichani M, Moerke N, Niepel, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.
Mol Syst Biol. 2015;11(3):0797.
Fallahi-Sichani M, Moerke N, Niepel, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.
Mol Syst Biol. 2015;11(3):0797.
Nair D, Monteiro J, Memmi G, Thanassi J, Pucci, Schwartzman J, Pinho M, Cheung A. Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens.
Antimicrob Agents Chemother. 2015;59(4):1876–1885.
Nair D, Monteiro J, Memmi G, Thanassi J, Pucci, Schwartzman J, Pinho M, Cheung A. Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens.
Antimicrob Agents Chemother. 2015;59(4):1876–1885.
2014
Gaun, Patchen, Volovertz, Zhen A, Andreev, Pollastri M, Fraenkel P. A chemical screen identifies small molecules that regulate hepcidin expression.
Blood Cells Mol Dis. 2014;53(4):231–40.
Gaun, Patchen, Volovertz, Zhen A, Andreev, Pollastri M, Fraenkel P. A chemical screen identifies small molecules that regulate hepcidin expression.
Blood Cells Mol Dis. 2014;53(4):231–40.
Herschhorn, Gu, Espy, Richard, Finzi, Sodroski J. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.
Nat Chem Biol. 2014;10(10):845–52.
Herschhorn, Gu, Espy, Richard, Finzi, Sodroski J. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.
Nat Chem Biol. 2014;10(10):845–52.
Sharma, Coen D. Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress.
J Virol . 2014;88(18):10982–5.
Sharma, Coen D. Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress.
J Virol . 2014;88(18):10982–5.
Chamoun-Emanuelli A, Pecheur E, Chen Z. Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C Virus.
Antiviral Res. 2014;109:141–8.
Chamoun-Emanuelli A, Pecheur E, Chen Z. Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C Virus.
Antiviral Res. 2014;109:141–8.
Chiaraviglio, Kirby J. Evaluation of Impermeant, DNA-Binding Dye Fluorescence as a Real-Time Readout of Eukaryotic Cell Toxicity in a High Throughput Screening Format.
Assay Drug Dev Technol. 2014;12(4):219–28.
Chiaraviglio, Kirby J. Evaluation of Impermeant, DNA-Binding Dye Fluorescence as a Real-Time Readout of Eukaryotic Cell Toxicity in a High Throughput Screening Format.
Assay Drug Dev Technol. 2014;12(4):219–28.
Matlack K, Tardiff D, Narayan, Hamamichi, Caldwell K, Caldwell G, Lindquist. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.
Proc Natl Acad Sci USA. 2014;111(11):4013–8.
Matlack K, Tardiff D, Narayan, Hamamichi, Caldwell K, Caldwell G, Lindquist. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.
Proc Natl Acad Sci USA. 2014;111(11):4013–8.
Rajamuthiah, Fuchs B, Jayamani, Kim Y, Larkins-Ford, Conery, Ausubel F, Mylonakis E. Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus.
PLoS One. 2014;9(2):e89189.
Rajamuthiah, Fuchs B, Jayamani, Kim Y, Larkins-Ford, Conery, Ausubel F, Mylonakis E. Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus.
PLoS One. 2014;9(2):e89189.
Beauchemin, Moerke N, Faloon, Kaye K. Assay Development and High-Throughput Screening for Inhibitors of Kaposi’s Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes.
J Biomol Screen. 2014;19:947–958.
Beauchemin, Moerke N, Faloon, Kaye K. Assay Development and High-Throughput Screening for Inhibitors of Kaposi’s Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes.
J Biomol Screen. 2014;19:947–958.
Derbyshire E, Zuzarte-Luís V, Magalhães A, Kato N, Sanschagrin P, Wang, Zhou W, Miduturu C, Mazitschek R, Sliz P, Mota M, Gray N, Clardy J. Chemical interrogation of the malaria kinome.
Chembiochem. 2014;15(13):1920–1930.
Derbyshire E, Zuzarte-Luís V, Magalhães A, Kato N, Sanschagrin P, Wang, Zhou W, Miduturu C, Mazitschek R, Sliz P, Mota M, Gray N, Clardy J. Chemical interrogation of the malaria kinome.
Chembiochem. 2014;15(13):1920–1930.
Vempati U, Chung, Mader, Koleti, Datar, Vidovic, Wrobel, Erickson, Muhlich J, Berriz, Benes C, Subramanian, Pillai, Shamu C, Schurer S. Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS) .
J Biomol Screen. 2014;19:803–816.
Vempati U, Chung, Mader, Koleti, Datar, Vidovic, Wrobel, Erickson, Muhlich J, Berriz, Benes C, Subramanian, Pillai, Shamu C, Schurer S. Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS) .
J Biomol Screen. 2014;19:803–816.
Seyedsayamdost M. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters.
Proc Natl Acad Sci U S A. 2014;111(20):7266–71.
Seyedsayamdost M. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters.
Proc Natl Acad Sci U S A. 2014;111(20):7266–71.