Small Molecule Publications
Acknowledging ICCB-L in Publications
Researchers using the services of ICCB-L staff or equipment agree to acknowledge the support of 'ICCB-Longwood Screening Facility at Harvard Medical School' in publications arising from your use of the facility. If an ICCB-L member has made an important intellectual contribution to the project, as determined by generally accepted criteria for academic collaborations, then that person should be considered for authorship on the publication. If your project was supported by a grant that also directly supports the ICCB-L, please consult the ICCB-L Director regarding the appropriate grant citation. Please notify Jen Smith upon public release of your publication.
Below is a list of publications that have resulted from small molecule screening efforts at ICCB-Longwood. Please notify us of your publications that involve use of the ICCB-Longwood Screening Facility.
2023
Kurmi, Liang D, vandeVen R, Georgiev P, Gassaway B, Han S, Notarangelo G, Harris I, Yao, Park J, Hu SH, Peng J, Drijvers J, Boswell S, Sokolov A, Dougan S, Sorger P, Gygi S, Sharpe A, Haigis M. Metabolic modulation of mitochondrial mass during CD4+ T cell activation.
Cell Chem Biol. 2023;30(9):1064–1075.
Kurmi, Liang D, vandeVen R, Georgiev P, Gassaway B, Han S, Notarangelo G, Harris I, Yao, Park J, Hu SH, Peng J, Drijvers J, Boswell S, Sokolov A, Dougan S, Sorger P, Gygi S, Sharpe A, Haigis M. Metabolic modulation of mitochondrial mass during CD4+ T cell activation.
Cell Chem Biol. 2023;30(9):1064–1075.
Du T, Song Y, Ray A, Wan X, Yao, Samur M, Shen C, Penailillo J, Sewastianik T, Tai YT, Fulciniti, Munshi N, Wu, Carrasco R, Chauhan D, Anderson K. Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma.
Blood. 2023;(Jan 11).
Du T, Song Y, Ray A, Wan X, Yao, Samur M, Shen C, Penailillo J, Sewastianik T, Tai YT, Fulciniti, Munshi N, Wu, Carrasco R, Chauhan D, Anderson K. Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma.
Blood. 2023;(Jan 11).
Yang JH, Petty C, Dixon-McDougall T, Lopez M, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin P, Arnold M, Li J, Martinez O, Behn A, Rogers-Hammond R, Angeli S, Gladyshev V, Sinclair D. Chemically induced reprogramming to reverse cellular aging.
2023;15(13):5966–5989.
Yang JH, Petty C, Dixon-McDougall T, Lopez M, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin P, Arnold M, Li J, Martinez O, Behn A, Rogers-Hammond R, Angeli S, Gladyshev V, Sinclair D. Chemically induced reprogramming to reverse cellular aging.
2023;15(13):5966–5989.
Potter D, Du R, Bohl S, Chow KH, Ligon K, Bueno R, Letai. Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma.
Nat Commun. 2023;14(2897).
Potter D, Du R, Bohl S, Chow KH, Ligon K, Bueno R, Letai. Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma.
Nat Commun. 2023;14(2897).
Ralvenius W, Mungenast A, Woolf H, Huston M, Gillingham T, Godin S, Penney J, Cam H, Gao F, Fernandez C, Czako B, Lightfoot Y, Ray W, Beckmann A, Goate A, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
J Exp Med. 2023;220(11):e20222105.
Ralvenius W, Mungenast A, Woolf H, Huston M, Gillingham T, Godin S, Penney J, Cam H, Gao F, Fernandez C, Czako B, Lightfoot Y, Ray W, Beckmann A, Goate A, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
J Exp Med. 2023;220(11):e20222105.
Quek R, Hardy K, Walker S, Nguyen D, Magalhães T, Salic, Gopalakrishnan S, Silver P, Mitchison T. Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity.
ACS Chem Biol. 2023;18(3):583–594.
Quek R, Hardy K, Walker S, Nguyen D, Magalhães T, Salic, Gopalakrishnan S, Silver P, Mitchison T. Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity.
ACS Chem Biol. 2023;18(3):583–594.
Yadav P, Papaioannou G, Kobelski M, Demay M. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes.
iScience. 2023;26(9):107548.
Yadav P, Papaioannou G, Kobelski M, Demay M. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes.
iScience. 2023;26(9):107548.
Sabag-Daigle A, Boulanger E, Thirugnanasambantham P, Law J, Bogard A, Behrman E, Gopalan V, Ahmer B. Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay.
Microbiol Spectr. 2023;11(2):e0460622.
Sabag-Daigle A, Boulanger E, Thirugnanasambantham P, Law J, Bogard A, Behrman E, Gopalan V, Ahmer B. Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay.
Microbiol Spectr. 2023;11(2):e0460622.
Lin, Chen DY, Scartelli C, Xie H, Merrill-Skoloff G, Yang M, Sun, Saeed M, Flaumenhaft. Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication.
iScience. 2023;26(9):107602.
Lin, Chen DY, Scartelli C, Xie H, Merrill-Skoloff G, Yang M, Sun, Saeed M, Flaumenhaft. Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication.
iScience. 2023;26(9):107602.
Sadeeshkumar H, Balaji A, Sutherland A, Mootien, Anthony K, Breaker R. Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch.
Anal Biochem. 2023;666:115047.
Sadeeshkumar H, Balaji A, Sutherland A, Mootien, Anthony K, Breaker R. Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch.
Anal Biochem. 2023;666:115047.
2022
Li, Chen J, Sun, Sparks R, Pantano L, Rahman RU, Moran S, Pondick J, Kirchner R, Wrobel, Bieler M, Sauer A, Sui S, Doerner J, Rippmann J, Mullen A. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells.
Elife. 2022;11(May 26).
Li, Chen J, Sun, Sparks R, Pantano L, Rahman RU, Moran S, Pondick J, Kirchner R, Wrobel, Bieler M, Sauer A, Sui S, Doerner J, Rippmann J, Mullen A. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells.
Elife. 2022;11(May 26).
Li D, Chaudhari S, Lee, Sojoodi M, Adhikari A, Zukerberg L, Shroff S, Barrett S, Tanabe K, Chung R, Devlin A. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury.
Sci Adv. 2022;8(34).
Li D, Chaudhari S, Lee, Sojoodi M, Adhikari A, Zukerberg L, Shroff S, Barrett S, Tanabe K, Chung R, Devlin A. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury.
Sci Adv. 2022;8(34).
Zhang HX, Heckman, Niday, Jo, Fujita, Shim, Pandey, Jandal H, Jayakar, Barrett L, Smith, Woolf C, Bean B. Cannabidiol activates neuronal Kv7 channels.
Elife. 2022;2022(11:e73246).
Zhang HX, Heckman, Niday, Jo, Fujita, Shim, Pandey, Jandal H, Jayakar, Barrett L, Smith, Woolf C, Bean B. Cannabidiol activates neuronal Kv7 channels.
Elife. 2022;2022(11:e73246).
Yang Y, Santos D, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black K, Spinney J, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager A, Seither P, Herrmann F, Medoff B. Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis.
Am J Respir Cell Mol Biol. 2022;67(1):36–49.
Yang Y, Santos D, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black K, Spinney J, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager A, Seither P, Herrmann F, Medoff B. Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis.
Am J Respir Cell Mol Biol. 2022;67(1):36–49.
Mills C, Subramanian, Hafner, Niepel, Gerosa L, Chung, Victor C, Gaudio B, Yapp C, Nirmal A, Clark N, Sorger P. Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.
Nat Commun. 2022;13(1):6918.
Mills C, Subramanian, Hafner, Niepel, Gerosa L, Chung, Victor C, Gaudio B, Yapp C, Nirmal A, Clark N, Sorger P. Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.
Nat Commun. 2022;13(1):6918.
Lee, Tran K, Vazquez-Uribe, Gotfredsen C, Clausen M, Mendez B, Montoya, Bach, Sommer M. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening.
J. Med. Chem. 2022;65(4):3266–3305.
Lee, Tran K, Vazquez-Uribe, Gotfredsen C, Clausen M, Mendez B, Montoya, Bach, Sommer M. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening.
J. Med. Chem. 2022;65(4):3266–3305.
Connor S, Rashid, Ryan K, Patel, Boyd J, Smith, Elyaman, Bennett D, Bradshaw E. GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease.
Front Cell Neurosci. 2022;16(May 23).
Connor S, Rashid, Ryan K, Patel, Boyd J, Smith, Elyaman, Bennett D, Bradshaw E. GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease.
Front Cell Neurosci. 2022;16(May 23).
Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, Buehler J, Stopka S, Regan M, Lin YF, Puliyappadamba V, Gao W, Khanal J, Evans L, Lee J, Guo L, Xiao Y, Xu M, Huang B, Jennings R, Bonal D, Martin-Sandoval M, Dang T, Gattie L, Cameron A, Lee S, Asara J, Kornblum H, Mak T, Looper R, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman M, Zacharias L, Mathews T, Losman JA, Richardson T, Cahill D, DeBerardinis R, Ligon K, Xu L, Ly P, Agar N, Abdullah K, Harris I, Kaelin W, McBrayer S. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Cancer Cell. 2022;40(9):939–956.
Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, Buehler J, Stopka S, Regan M, Lin YF, Puliyappadamba V, Gao W, Khanal J, Evans L, Lee J, Guo L, Xiao Y, Xu M, Huang B, Jennings R, Bonal D, Martin-Sandoval M, Dang T, Gattie L, Cameron A, Lee S, Asara J, Kornblum H, Mak T, Looper R, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman M, Zacharias L, Mathews T, Losman JA, Richardson T, Cahill D, DeBerardinis R, Ligon K, Xu L, Ly P, Agar N, Abdullah K, Harris I, Kaelin W, McBrayer S. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Cancer Cell. 2022;40(9):939–956.
Strang B. Toward inhibition of human cytomegalovirus replication with compounds targeting cellular proteins.
J Gen Virol. 2022;103(10).
Strang B. Toward inhibition of human cytomegalovirus replication with compounds targeting cellular proteins.
J Gen Virol. 2022;103(10).
Muscato J, Morris H, Mychack A, Rajagopal M, Baidin, Hesser A, Lee, İnecik K, Wilson L, Kraml C, Meredith T, Walker S. Rapid Inhibitor Discovery by Exploiting Synthetic Lethality.
J Am Chem Soc. 2022;144(8):3696–3705.
Muscato J, Morris H, Mychack A, Rajagopal M, Baidin, Hesser A, Lee, İnecik K, Wilson L, Kraml C, Meredith T, Walker S. Rapid Inhibitor Discovery by Exploiting Synthetic Lethality.
J Am Chem Soc. 2022;144(8):3696–3705.
Kuiken H, Dhakal, Selfors L, Friend C, Zhang T, Callari M, Schackmann R, Gray G, Crowdis J, Bhang H, Baslan T, Stegmeier F, Gygi S, Caldas C, Brugge J. Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts.
Oncogene. 2022;41(1):112–124.
Kuiken H, Dhakal, Selfors L, Friend C, Zhang T, Callari M, Schackmann R, Gray G, Crowdis J, Bhang H, Baslan T, Stegmeier F, Gygi S, Caldas C, Brugge J. Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts.
Oncogene. 2022;41(1):112–124.
Boivin B, Roet K, Huang X, Karhohs K, Rohban M, Sandoe J, Wiskow O, Maeda R, Grantham A, Dornon M, Shao J, Frost D, Baker D, Eggan K, Carpenter A, Woolf C. A multiparametric activity profiling platform for neuron disease phenotyping and drug screening.
Mol Biol Cell. 2022;33(6):ar54.
Boivin B, Roet K, Huang X, Karhohs K, Rohban M, Sandoe J, Wiskow O, Maeda R, Grantham A, Dornon M, Shao J, Frost D, Baker D, Eggan K, Carpenter A, Woolf C. A multiparametric activity profiling platform for neuron disease phenotyping and drug screening.
Mol Biol Cell. 2022;33(6):ar54.
Tharappel A, Li Z, Zhu Y, Wu X, Chaturvedi S, Zhang Q, Li H. Calcimycin Inhibits Cryptococcus neoformansIn Vitro and In Vivo by Targeting the Prp8 Intein Splicing.
ACS Infect Dis. 2022;8(9):1851–1868.
Tharappel A, Li Z, Zhu Y, Wu X, Chaturvedi S, Zhang Q, Li H. Calcimycin Inhibits Cryptococcus neoformansIn Vitro and In Vivo by Targeting the Prp8 Intein Splicing.
ACS Infect Dis. 2022;8(9):1851–1868.
Yao, D’Agostino G, Park, Hang S, Adhikari A, Zhang Y, Li, Avila-Pacheco J, Bae S, Clish C, Franzosa E, Huttenhower C, Huh J, Devlin A. A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria.
Nat Microbiol. 2022;7(9):1404–1418.
Yao, D’Agostino G, Park, Hang S, Adhikari A, Zhang Y, Li, Avila-Pacheco J, Bae S, Clish C, Franzosa E, Huttenhower C, Huh J, Devlin A. A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria.
Nat Microbiol. 2022;7(9):1404–1418.
2021
Chaudhari S, Devlin A. Intestinal Co-culture System to Study TGR5 Agonism and Gut Restriction.
Bio Protoc. 2021;11(6):e3948.
Chaudhari S, Devlin A. Intestinal Co-culture System to Study TGR5 Agonism and Gut Restriction.
Bio Protoc. 2021;11(6):e3948.
Finardi N, Hernandez L, Russell M, Ho CK, Sreenu V, Wenham H, Merritt, Strang B. Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication.
J Gen Virol. 2021;102(12):001702.
Finardi N, Hernandez L, Russell M, Ho CK, Sreenu V, Wenham H, Merritt, Strang B. Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication.
J Gen Virol. 2021;102(12):001702.
Baidin, Owens T, Lazarus, Kahne. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
J Am Chem Soc. 2021;(Jan 7).
Baidin, Owens T, Lazarus, Kahne. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
J Am Chem Soc. 2021;(Jan 7).
Tao J, Campbell J, Tsai L, Wu C, Liberles S, Lowell B. Highly selective brain-to-gut communication via genetically defined vagus neurons.
Neuron. 2021;109(13):2106–2115.
Tao J, Campbell J, Tsai L, Wu C, Liberles S, Lowell B. Highly selective brain-to-gut communication via genetically defined vagus neurons.
Neuron. 2021;109(13):2106–2115.
Perry E, Bennett C, Luo, Balsa, Jedrychowski, KE.O’Malley, Latorre-Muro, Ladley R, Reda, Wright P, Gygi S, Myers A, Puigserver. Tetracyclines promote survival and fitness in mitochondrial disease models .
Nature Metabolism. 2021;3:33–42.
Perry E, Bennett C, Luo, Balsa, Jedrychowski, KE.O’Malley, Latorre-Muro, Ladley R, Reda, Wright P, Gygi S, Myers A, Puigserver. Tetracyclines promote survival and fitness in mitochondrial disease models .
Nature Metabolism. 2021;3:33–42.
Potter D, Du R, Bhola P, Bueno R, Letai. Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer.
Cell Death Dis. 2021;12(8).
Potter D, Du R, Bhola P, Bueno R, Letai. Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer.
Cell Death Dis. 2021;12(8).