Fee Summary

A fee is charged for access to ICCB-Longwood. This fee helps us to recover some of our operating expenses. ICCB-Longwood fees (and associated Facilities and Administration (F&A) fees) are revised annually based upon the Harvard Fiscal Year (July 1 – June 30). New fees are typically recalculated in September or October of each year. The fee structure is updated on the ICCB-Longwood website as soon as it is available. All charges are based on the fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below apply to screening activities carried out in FY17 (July 1, 2016 – June 30, 2017). We anticipate these fees will be in effect until Fall 2017, at which time the FY18 fees should be calculated and available.

The fees charged for access to ICCB-Longwood do not include the cost of screening reagents and supplies. Funding for all screening reagents and supplies is the responsibility of the screener.

Non-academic investigators should contact Jennifer Smith for the current industry price structure.

Small Molecule Screening Fees

Fees for HMS Internal Quad Screens

 

Screening Milestone
Fees 
Screen set-up fee$4,319
Additional fee for screening up to 5,000 experimental wells

$2,159

Additional fee for screening 5,001-10,000 experimental wells$1,800
Additional fee for screening 10,001-25,000 experimental wells$2,519
Additional fee for screening 25,001-50,000 experimental wells$3,599
Additional fee for screening 50,001-100,000 experimental wells$3,599
Fee for screening additional increments of 100,000 experimental wells$5,344

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $2.75 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Small Molecule Fees - HMS Affiliates and Non-Harvard Academic

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$4,319
$1,014
Additional fee for screening up to 5,000 experimental wells
$2,159
$507
Additional fee for screening 5,001-10,000 experimental wells
$1,800
$423
Additional fee for screening 10,001-25,000 experimental wells
$2,519
$592
Additional fee for screening 25,001-50,000 experimental wells
$3,599
$845
Additional fee for screening 50,001-100,000 experimental wells
$3,599
$846
Fee for screening additional increments of 100,000 experimental wells
$5,344
$1,256

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of theexperimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $2.75 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

RNAi Screening Fees

Fees for HMS Internal Quad Screens

Screening Milestone
Fees
RNAi screen set-up fee
$3,226
Additional fee for screening one full genome siRNA library
$10,801
Additional fee for screening lncRNA siRNA library

$1,112

Additional fee for screening each miRNA reagent library

$794

In lieu of screening the full human genome library, it is possible to screen smaller, focused libraries: 
 Additional fee per library for screening: Phosphatases, Ubiquitin Conjugating Enzymes #1 or Ubiquitin Conjugating Enzymes #2$159
 Additional fee per library for screening: G-protein Coupled Receptors, Ion Channels, Proteases or Ubiquitin Conjugating Enzymes #3 $317.67
 Additional fee for screening: Kinases$476.51

The above full-genome screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $1.50 per duplex picked ($6 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

Fees for HMS-Affiliated and Non-Harvard Academic Screens

Screening Milestone
Fees 
Corresponding F&A
RNAi screen set-up fee
$4,033
$972
Additional fee for screening one full genome siRNA library
$13,501
$3,255
Additional fee for screening lncRNA siRNA library

$1,390

$294

Additional fee for screening each miRNA reagent library

$993

$210

In lieu of screening the full human genome library, it is possible to screen smaller, focused libraries:
 Additional fee per library for screening: Phosphatases, Ubiquitin Conjugating Enzymes #1 or Ubiquitin Conjugating Enzymes #2$199 $42
 Additional fee per library for screening: G-protein Coupled Receptors, Ion Channels, Proteases or Ubiquitin Conjugating Enzymes #3$397 $84
 Additional fee for screening: Kinases $596 $126

The above full-genome screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $1.50 per duplex picked ($6 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

Instrument Training and Access Fees

Instrument Training and Access Fees

  • Investigators utilizing instrumentation at ICCB-Longwood and not conducting a small molecule or RNAi screen will be charged a fee for access.
  • A one-time training fee will be charged for each individual on each instrument they are trained.
  • For individuals originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard investigators), the F&A fee will be assessed at the time the fee is charged.  
  • In addition, there is a per-instrument annual access fee to help recover a portion of the costs associated with instrument maintenance.
 Fees for HMS Internal Quad InvestigatorsFees for HMS-Affiliated and Non-Harvard Academic Investigators
Instrument Training
$134
$134
Instrument Annual Access
$228
$228
F&A Fee N/A$13

qPCR Training and Access Fees

qPCR Training and Access Fees

  • A one-time training fee will be charged for each individual who is trained on each QPCR instrument.
  • For individuals originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard investigators), the Facilities and Administration (F&A) fee will be assessed at the time the fee is charged.  
  • In addition, there is an annual access fee to help recover a portion of the costs associated with instrument maintenance.

 
Fees for HMS Internal Quad Investigator
Fees for HMS-Affiliated and Non-Harvard Academic Investigators
QPCR Training
$134
$134
QPCR Annual Access
$215
$215
F&A Fee
N/A
$91

Custom Lab Automation Project Fees

Custom Lab Automation Fees

  • Custom lab automation projects can be performed by ICCB-L Staff as time allows.
  • Hourly time charged includes planning, consultation, and program calibration at ICCB-L, in addition to the actual automation.
  • For individuals from non-HMS Quad labs (including HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard screeners), the F&A will be assessed at the time the fee is charged.
 
Fees for HMS Internal Quad Investigators
Fees for HMS-Affiliated and Non-Harvard Academic Investigators
Custom Lab Automation Projects
$116/hour
$116/hour
F&A Fee
N/A
$35/hour

ImageXpress Micro Project Fees

ImageXpress Micro Project Fees

  • There is an annual fee of $1,884 + F&A (if applicable) assessed for imaging projects that utilize the ImageXpress Micro and are not ICCB-Longwood small molecule or RNAi screens.
  • For individuals originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and non-Harvard investigators), the F&A fee will be assessed at the time the fee is charged. 
  • To discuss whether your proposed use of the ImageXpress Micro is subject to the annual fee, please contact Jennifer Smith
 
Fees for HMS Internal Quad Projects
Fees for HMS-Affiliated and Non-Harvard Projects
ImageXpress Micro Imaging Projects
$1,884
$1,884
F&A Fee
N/A
$699