Fee Summary

Fees are charged for screens and equipment use at ICCB-Longwood. These fees help us to recover a portion of our operating expenses. ICCB-Longwood fees (and associated Facilities and Administration (F&A) fees) are revised annually based upon the Harvard Fiscal Year (July 1 – June 30). The fee structure is updated on the ICCB-Longwood website as soon as it is available. All charges are based on the fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below represent the rates for FY24 (July 1, 2023 - June 30, 2024).

The fees charged for access to ICCB-Longwood do not include the cost of screening reagents and supplies. Funding for all screening reagents and supplies is the responsibility of the screener.

Non-academic investigators should contact Jennifer Smith for the current industry price structure.

Small Molecule Screening Fees

Fees for HMS Internal Quad Screens

Screening Milestone
Fees 
Screen set-up fee $5,927
Additional fee for screening up to 5,000 experimental wells

$2,964

Additional fee for screening 5,001-10,000 experimental wells $2,470
Additional fee for screening 10,001-25,000 experimental wells $3,458
Additional fee for screening 25,001-50,000 experimental wells $4,939
Additional fee for screening 50,001-100,000 experimental wells $4,939
Fee for screening additional increments of 100,000 experimental wells $7,335

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Small Molecule Fees - HMS Affiliates and Non-Harvard Academic

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$5,927
$1,186
Additional fee for screening up to 5,000 experimental wells
$2,964
$593
Additional fee for screening 5,001-10,000 experimental wells
$2,470
$494
Additional fee for screening 10,001-25,000 experimental wells
$3,458
$692
Additional fee for screening 25,001-50,000 experimental wells
$4,939
$988
Additional fee for screening 50,001-100,000 experimental wells
$4,939
$988
Fee for screening additional increments of 100,000 experimental wells
$7,335
$1,467

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Functional Genomics Screening Fees

Fees for HMS Internal Quad Screens

Screening Milestone
Fees
Screen set-up fee
$5,927
Additional fee for screening full Synthego Druggable sgRNA CRISPR library (29 plates)
$8,247
Additional fee for screening one full genome siRNA library (66 plates)
$18,770
Per library plate fee

$284

Additional fee for screening lncRNA siRNA library

$1,991

Additional fee for screening each miRNA library $1,422
 Additional fee per library for screening: GPCR, Ion Channels, Proteases or Ubiquitin  $569
 Additional fee for screening Kinases $853

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $4 per duplex picked ($16 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Fees for HMS-Affiliated and Non-Harvard Academic Screens

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$5,927
$1,186
Additional fee for screening full Synthego Druggable sgRNA CRISPR library (29 plates)
$8,247
$1,649
Additional fee for screening one full genome siRNA library (66 plates)
$18,770
$3,754
Per library plate fee

$284

$57

Additional fee for screening lncRNA siRNA library

$1,991

$399

 Additional fee for screening each miRNA library $1,422  $285
 Additional fee per library for screening: GPCR, Ion Channels, Proteases or Ubiquitin $569  $114
 Additional fee for screening Kinases  $853  $171

The above full-genome siRNA screening fee includes cherry picks for 1,200 individual siRNA duplexes (representing 300 genes) for each screen. Additional cherry picks can be requested at $4 per duplex picked ($16 per gene). Cherry picks can only be requested for individual duplexes, not for SMARTpool reagents. It is not possible to request a cherry pick from Human Pilot 1.

The above full druggable sgRNA CRISPR fee includes a cherry pick of 150 sgRNAs for each screen.

Instrument Training and Use Fees

Instrument Training

  • Investigators not conducting a small molecule or functional genomics screen can access ICCB-Longwood instrumentation. They are charged an initial training fee and subsequent independent use is charged hourly.
  • A training fee will be charged for each individual on each instrument they are trained.
  • HMS charges a Facilities and Administration (F&A) fee to HMS Affiliates and non-Harvard labs.

Training Fee

Instrument  Academic   Corresponding F&A 
High Content (IXM-C, IXM-C LZR, Acumen, iQue) $338 $68
Bravo (hourly) $122 $25
Other Instruments (except High Content and Bravo)  $143 $29

Instrument Use

  • Instrument use that is not part of an approved small molecule or functional genomics screen is charged hourly based on reserved and actual time used. Session cancellations must be made more than 24 hours in advance to avoid booking fees.
  • PPMS is used for instrument reservations and calculates the time used.
  • HMS charges a Facilities and Administration (F&A) fee to HMS Affiliates and non-Harvard labs.

Hourly Use Charges

Instrument

 Hourly Rate Academic 

 Corresponding F&A 
Acumen
$32
$6.40
EnVision
$22
$4.40
FlexStation  $22 $4.40
HPD300
$15
$3.00
iQue
$54
$10.80
IXM-C and IXM-C LZR
$40
$8.00
qPCR
$22
$4.40
User Bravo
$72
$14.40

Annual Access

Instrument

 Academic 

 Corresponding F&A 
Combi
$275
$55
PlateLoc
$275
$55
Plate Washer  $275 $55

Custom Lab Automation Projects

Custom Lab Automation

  • Custom lab automation projects can be performed by ICCB-L team members.
  • Hourly time charged includes planning, consultation, and program calibration at ICCB-L, in addition to the actual automation.
  • HMS charges a Facilities and Administration (F&A) fee to HMS Affiliates and non-Harvard labs.
 
 Hourly Rate Academic 
 Corresponding F&A 
 Custom Lab Automation Projects 
$122
$25