LINCS 3 - Chromatin Targeting Library

The compounds in this collection were selected for HMS LINCS and purchased from a variety of vendors. ICCB-Longwood’s portion of this library was paid for by an NIH Center grant to Dr. Alan D’Andrea (DFCI) in May 2013 and plated in July 2013.

Each compound is plated at 4 concentrations (10 mM, 2 mM, 0.4 mM and 0.08 mM). The concentrations of the compounds on this library plate are according to quadrant; Quadrant A1 is at 10mM, Quadrant A2 is at 2mM, Quadrant B1 is at 0.4mM and Quadrant B2 is at 0.08mM, please see map below for a visual layout.

Number of Compounds:

41 (x 4 concentrations)

164 wells

Plate Numbers:
3426 (1 Plate)
Concentration Information:
0.08mM, 0.4mM, 2mM, 10mM in DMSO

 

Plate 3426
384-Well Plate Format

 This is a collection of compounds that inhibit proteins characterized to interact with and/or impact chromatin structure and function.  Targets include histone deacetylases, DNA methyltransferases, polyADP ribose polymerases, histone acetyl transferases, sirtuins, histone lysine methyltransferases, histone lysine demethylases, bromodomains, methyl mark readers, HIF-1alpha prolyl hydroxylase-2, telomerase, and RNA polymerase I.

Please refer to the HMS LINCS website and HiTS Small Molecule Suite for more detailed information about the contents of this library.