ChemBridge Focused Nuclear Hormone Receptor-Based Core

This is a focused collection that was jointly purchased by an NIH Center grant to Dr. Alan D’Andrea (DFCI) and the Assay Development and Screening Facility (Boston Children's Hospital) in December 2012 and plated in January 2013. It contains 250 compounds selected from ChemBridge’s larger Nuclear Hormone Receptor-Biased Core (NHRCore) Library, which is a computationally selected library of more than 1,200 small molecules selected from ChemBridge’s CORE Library. Compounds were selected using pharmacophores generated from known nuclear hormone receptor actives. There are 10 targets (androgen receptor, estrogen receptor, estrogen receptor modulator, farnesoid X receptor, glucocorticoid receptor, liver X receptor, PPAR, progesterone receptor, RAR, and vitamin D receptor) covered in this library by 16 different scaffolds, with each scaffold having a minimum of 5 compounds.

Number of Compounds 250
Plate Numbers 3409 (1 Plate)
Concentration Information 10 mM in DMSO

384-well Plate Format

Chembridge NHBR Core Information.pdf95 KB

For specific scaffold information please see attached file.

The ChemBridge website contains additional information on the NHRCore Library.

Ordering Compounds from ChemBridge:

ChemBridge Corp.
11199 Sorrento Valley Road, Suite 206
San Diego, CA, 92121

Customer Support
Ph: 800-964-6143, Press 4
E-mail: support@chembridge.com

Ordering Options

To order ChemBridge compounds: 

Order online using a purchase order number or a credit card using ChemBridge’s www.hit2lead.com site. Online orders for screening compounds receive discounted online pricing. Users placing orders online also have access to RUSH samples (1mg or 5mg pre-weighed vials) stored in ChemBridge’s San Diego RUSH stock and available for delivery within 24 to 48 hours after placing an order. See additional information below on using www.hit2lead.com to place online orders.

Order by contacting ChemBridge Customer Support – see contact information below:

Phone: 800-964-6143, Press 4
support@chembridge.com

Hit2 Lead Instructions

Placing order online using ChemBridge’s Hit2Lead.com Online Store:

Access the site by going directly to www.hit2lead.com or by going to www.chembridge.com and clicking on the Online Store image.

Hit2Lead.com supports searches of ChemBridge stock based on chemical structure, ChemBridge ID number, or compound name. The structure-based search function uses Java-based applets that automatically download (Marvin sketcher from ChemAxon or JDraw sketcher from Accelrys).

Searches can be run without an account. Account registration is required when you are ready to place an order.

To search by structure (exact match or substructure), select Structure Search, then select Marvin or JDraw and then double-click on the “Structure Field” blank box to launch the sketcher.

Enter the structure of the compound you wish to query and then on the main Search page select whether you want to perform an exact match or Substructure Search, Exact Match, or Similarity Search. Click the Search button at the bottom of the page to launch the search.

For each desired compound, select an amount and add to basket. Some compounds (1 mg or 5 mg amounts) can be shipped RUSH in 24-48 hours, with an extra charge (pre-weighed 1mg or 5mg RUSH vials are indicated by the word “Rush” after the amount).

RUSH samples will ship from San Diego stock within 24-48 hours; standard samples will ship from ChemBridge’s Moscow facility and arrive within 2 weeks. NOTE: resupply of 100% of the compounds is not guaranteed due to availability and difficulty of re-synthesis. Generally, 75% are available for re-order.

To search by compound number, click “Search by ID”. The ChemBridge ID number of each compound can be found in the “Object Name” field in the SARgen search report. Place the digit “5″ before this number when ordering from Hit2Lead.com. For example, if the object name of the Chembridge compound is ****** in ActivityBase/SARgen, then enter 5****** in the “ID” box in the Hit2Lead.com “Search by ID” page.

Once all compounds have been placed in the basket, proceed to order your basket, and confirm the order information. Click on “proceed” and then “proceed to order” to open the billing screen. This screen summarizes the order cost including shipping and applicable taxes. Use this information to obtain a Purchase Order number from the financial office in your lab or department. A PO number is required to process the order. You can quickly retrieve your saved basket, add the PO number, and complete the order.

To request a quotation for re-synthesis of a compound, contact ChemBridge Customer Support at support@chembridge.com.