ChemBridge Focused Kinase-Based Core

This is a focused collection that was jointly purchased by an NIH Center grant to Dr. Alan D’Andrea (DFCI) and the Assay Development and Screening Facility (Boston Children's Hospital) in December 2012 and plated in January 2013. It contains 250 compounds selected from ChemBridge’s larger kinase-biased KINACore Library, which is a computationally selected library of more than 6,000 small molecules selected from ChemBridge’s CORE Library. Compounds were selected using pharmacophores generated from known kinase actives or are predicted to interact with the ATP ligand site of kinases. There are 34 targets (ADK, Aurora, BRAF, CDK, CDK2, CDK5, CHK1, C-MET, CSFR1, EGFR, FGFR, GRK2, GSK, HER, IKK, IRAK, JAK, JNN, LCK, MYT-1, P38 MAP, PDGFR, PI3K, PKA, PKB, PKC, PLK1, RAF, SRC, SYK, TGFR, TIE2, TK, VEGFR) covered in this library by 16 different scaffolds, with each scaffold having a minimum of 5 targets.

Number of Compounds
250
Plate Numbers
3410 (1 Plate)
Concentration Information
10 mM in DMSO

384-well Plate Format

For specific scaffold information please see the attached file.

The ChemBridge website contains additional information on the KINACore Library.

Ordering Compounds from ChemBridge:

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