ChemBridge Focused G-Protein Coupled Receptor Library

This is a focused collection that was jointly purchased by an NIH Center grant to Dr. Alan D’Andrea (DFCI) and the Assay Development and Screening Facility (Boston Children's Hospital) in December 2012 and plated in January 2013. It contains 250 compounds selected from ChemBridge’s larger GPCR Library of over 13,000 novel compounds. This focused collection has 11 different scaffolds, with each scaffold having 19-24 compounds.

Number of Compounds
250
Plate Numbers
3407 (1 Plate)
Concentration Information
10 mM in DMSO

384-well Plate Format

Compounds were chosen based on availability and the following drug-like physiochemical property filters:

MW < 500 (range 225 to < 500)
cLogP < 5 (range -0.27 to 4.96)
H-bond Donors < 5 (range 0 to 4)
H-bond Acceptors < 10 (range 3 to 9)
tPSA <140 (Range 35 to 122)
Rotatable Bonds range 1 to 15

For specific scaffold information please see attached file.

The ChemBridge website contains additional information on the GPCR Library.

Ordering Compounds from ChemBridge:

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