Below is a list of publications that have resulted from small molecule screening efforts at ICCB-Longwood. Please notify us of your publications that involve use of the ICCB-Longwood Screening Facility.
Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E. A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature 2018;556(7699):103-107.
Liao J, Xu G, Mevers EE, Clardy J, Watnick PI. A high-throughput, whole cell assay to identify compounds active against carbapenem-resistantKlebsiella pneumoniae. PLoS ONE 2018;13(12):e0209389.
Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep 2018;23(10):3091-3101.
Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D. Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors. PNAS 2018;115(26):6834-6839.
Gonzalez KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep 2018;22(8):1945-1955.
Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J. Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death. Cell Death Dis. 2018;9(2):138.
Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Scientific Reports 2017;7(44867)
Hafner M, Niepel M, Subramanian K, Sorger PK. Designing drug response experiments and quantifying their results . Curr Protoc Chem Biol 2017;9(2):96-116.
Niepel M, Hafner M, Chung M, Sorger PK. Measuring cancer drug sensitivity and resistance in cultured cells. Curr Protoc Chem Biol 2017;9(2):55-74.
Abrial M, Paffett-Lugassy N, Jeffrey S, Jordan D, O'Laughlin E, Frederick CJ, Burns CG, Burns CE. TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation. Cell Rep 2017;20(4):973-983.
Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol 2017;13(2):218-225.
Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB. Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacteriumand Potentiates Antibiotics. Cell Chem Biol 2017;24(8):993-1004.
Strang BL. RO0504985 is an inhibitor of CMGC kinase proteins and has anti-human cytomegalovirus activity [Internet]. Antiviral Res 2017;144:21-26. Publisher's Version
Maura D, Drees SL, Bandyopadhaya A, Kitao T, Negri M, Starkey M, Lesic B, Milot S, Deziel E, Zahler R, Pucci M, Felici A, Fetzner S, Lepine F, Rahme LG. Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance. ACS Chem Bio 2017;:[Epub ahead of print].
Khan AS, Murray MJ, Ho CM, Zuercher WJ, Reeves MB, Strang BL. High Throughput Screening of a GlaxoSmithKline Protein Kinase Inhibitor Set Identifies an Inhibitor of Human Cytomegalovirus Replication that Prevents CREB and Histone H3 Post-Translational Modification. J Gen Virol 2017;Epub ahead of print:doi:10.1099/jgv.0.000713.
Beelontally R, Wilkie GS, Lau B, Goodmaker CJ, Ho CMK, Swanson CM, Deng X, Wang J, Gray NS, Davison AJ, Strang BL. Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins. Antiviral Res 2017;138:61-70.
Fuchs B, Rajamuthiah R, Souza AC, Eatemadpour S, Rossoni RD, Santos DA, Junqueira JC, Rice LB, Mylonakis E. Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin. Future Med Chem 2016;8(2):117-132.
Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, 4th LRH, Jedrychowski M, Vogel R, Paulo JA, Smeitinik J, Gygi SP, Doench J, Root DE, Puigserver P. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Mol Cell 2016;64(1):163-175.
Bird GH, Mazzola E, Opoku-Nsiah K, Lammert MA, Godes M, Neuberg DS, Walensky LD. Biophysical Determinants for Cellular Uptake of HydrocarbonStapled Peptide Helices. Nat Chem Biol 2016;12(10):845-52.
Chiaraviglio L, Kang YS, Kirby JE. High Throughput, Real-time, Dual-readout testing of intracellular antimicrobial activity and eukaryotic cell cytotoxicity. J Vis Exp 2016;117:doi: 10.3791/54841.
de Wispelaere M, Carocci M, Liang Y, Liu Q, Sun E, Vetter ML, Wang J, Gray NS, Yang PL. Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Res 2016;139:171-179.
Balasubramanian A, Manzano M, Teramoto T, Pilankatta R, Padmanabhan R. High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Res 2016;134:6-16.
Helenius IT, Nair A, Bittar HE, Sznaider JI, Sporn PH, Beitel GJ. Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. J Biomol Screen 2016;21(4):363-71.
Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Naar AM, Arthanari H. Inhibiting fungal multidrug resistance by disrupting an activator-mediator interaction. Nature 2016;530(7591):485-9.
Zervantonakis IK, Arvanitis CD. Controlled drug release and chemotherapy response in a novel acoustofluidic 3D tumor platform. Small 2016;12(19):2616-26.
Clark MJ, Miduturu C, Schmidt AG, Zhu X, Pitts JD, Wang J, Zhang J, Wojciechowski A, Chu JJ-H, Potisopon S, Gray NS, Yang PL. GNF-2 inhibits dengue virus by targeting Abl Kinases and the viral E protein. Cell Chemical Biology 2016;23(4):443-52.
Smith KP, Kirby JE. Validation of a High-Throughput Screening Assay for Identification of Adjunctive and directly Acting Antimicrobials Targeting Carbapenem-Resistant Enterobacteriaceae. Assay Drug Dev Technol 2016;14(3):194-206.
Clark MJ, Midituru C, Schmidt AG, Zhu X, Pitts JD, Wang J, Potisopon S, Zhang J, Wojciechowski A, Chu JJH, Gray NS, Yang PL. GNF-2 Inhibits Dengue Virus by Targeting ABI Kinases and the Viral E Protein. Cell Chem Biol 2016;23(4):443-52.
Carocci M, Yang PL. Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Res 2016;128:57-62.
Adler M, Ramm S, Hather M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol 2016;27(4):1015-28.
