# Small Molecule Publications ## Acknowledging ICCB-L in Publications Researchers using the services of ICCB-L staff or equipment agree to acknowledge the support of '*ICCB-Longwood Screening Facility at Harvard Medical School*' in publications arising from your use of the facility. If an ICCB-L member has made an important intellectual contribution to the project, as determined by generally accepted criteria for academic collaborations, then that person should be considered for authorship on the publication. If your project was supported by a grant that also directly supports the ICCB-L, please consult the ICCB-L Director regarding the appropriate grant citation. Please notify Jen Smith upon public release of your publication. Below is a list of publications that have resulted from small molecule screening efforts at ICCB-Longwood. Please notify us of your publications that involve use of the ICCB-Longwood Screening Facility. Download 405 citations download- [BibTeX](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=tagged) - [Marc](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=marc) - [PubMedId](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=standard_pager&number_of_items=30&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_publicationcategory%5D%5B0%5D%5Btarget_id%5D=110771&&&format=ris) ### 2026 Petrova V, Mills CE, Hug C, Cetinkaya-Fisgin A, Splaine J, Fouladzadeh S, Hakim S, Powell R, Zhen S, Chung M, Bradshaw GA, Deng T, Singec I, Wang Q, Kawaguchi R, Jonnagaddala H, Barrett LB, Smith JA, Kalocsay M, Gyori BM, Hoke A, Sorger PK, Woolf CJ. [A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy](/publication/human-ipsc-derived-sensory-neuron-platform-high-throughput-discovery-neuroprotectants). Cell Reports Medicine. Elsevier; 2026; Petrova V, Mills CE, Hug C, Cetinkaya-Fisgin A, Splaine J, Fouladzadeh S, Hakim S, Powell R, Zhen S, Chung M, Bradshaw GA, Deng T, Singec I, Wang Q, Kawaguchi R, Jonnagaddala H, Barrett LB, Smith JA, Kalocsay M, Gyori BM, Hoke A, Sorger PK, Woolf CJ. [A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy](/publication/human-ipsc-derived-sensory-neuron-platform-high-throughput-discovery-neuroprotectants). Cell Reports Medicine. Elsevier; 2026; - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://doi.org/10.1016/j.xcrm.2026.102787) Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of cancer treatment, yet the lack of predictive human models continues to hinder therapeutic progress. Here, we establish a scalable and reproducible model of... - [ descriptionPublisher's Version](https://doi.org/10.1016/j.xcrm.2026.102787) ### 2025 Bharath N, DiPietro E, Durfee O, Kycia I, Splaine J, Sethupathy P, Rogers MS, Vakili K. [A novel high-throughput screening platform to identify inhibitors of DNAJB1-PRKACA-driven transcriptional activity in fibrolamellar carcinoma.](https://pubmed.ncbi.nlm.nih.gov/39947627/) SLAS discovery : advancing life sciences R & D. 2025;32:100221. PMID: 39947627 Bharath N, DiPietro E, Durfee O, Kycia I, Splaine J, Sethupathy P, Rogers MS, Vakili K. [A novel high-throughput screening platform to identify inhibitors of DNAJB1-PRKACA-driven transcriptional activity in fibrolamellar carcinoma.](https://pubmed.ncbi.nlm.nih.gov/39947627/) SLAS discovery : advancing life sciences R & D. 2025;32:100221. PMID: 39947627 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000140) Fibrolamellar carcinoma (FLC) is a primary liver cancer with a poor prognosis, primarily due to the lack of effective chemotherapeutic options. The DNAJB1-PRKACA (DP) gene fusion is recognized as the key oncogenic driver in FLC. This fusion arises from a... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000140) Law JD, Gao Y, Kovvali S, Thirugnanasambantham P, Wysocki VH, Ahmer BMM, Gopalan V. [Identification of inhibitors of the Salmonella FraB deglycase, a drug target.](https://pubmed.ncbi.nlm.nih.gov/39945759/) FEBS open bio. 2025; PMID: 39945759 Law JD, Gao Y, Kovvali S, Thirugnanasambantham P, Wysocki VH, Ahmer BMM, Gopalan V. [Identification of inhibitors of the Salmonella FraB deglycase, a drug target.](https://pubmed.ncbi.nlm.nih.gov/39945759/) FEBS open bio. 2025; PMID: 39945759 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.70001) Nontyphoidal Salmonella is one of the most prevalent causes of human foodborne illnesses worldwide, with no narrow-spectrum antibiotics or vaccines available. Here, we seek to address this gap. During the host inflammatory response, Salmonella metabolizes... - [ descriptionPublisher's Version](https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.70001) Quek RT, Shirazinejad CR, Young CL, Hardy KS, Lim S, Elms PJ, McSwiggen DT, Mitchison TJ, Silver PA. [Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein.](https://pubmed.ncbi.nlm.nih.gov/39894078/) SLAS discovery : advancing life sciences R & D. 2025;31:100220. PMID: 39894078 Quek RT, Shirazinejad CR, Young CL, Hardy KS, Lim S, Elms PJ, McSwiggen DT, Mitchison TJ, Silver PA. [Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein.](https://pubmed.ncbi.nlm.nih.gov/39894078/) SLAS discovery : advancing life sciences R & D. 2025;31:100220. PMID: 39894078 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000139) Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000139) ### 2024 Niu X, Melendez DL, Raj S, Cai J, Senadeera D, Mandelbaum J, Shestopalov IA, Martin SD, Zon LI, Schlaeger TM, Lai LP, McMahon AP, Craft AM, Galloway JL. [A conserved transcription factor regulatory program promotes tendon fate.](https://pubmed.ncbi.nlm.nih.gov/39216481/) Developmental cell. 2024;59(23):3106–3123.e12. PMID: 39216481 Niu X, Melendez DL, Raj S, Cai J, Senadeera D, Mandelbaum J, Shestopalov IA, Martin SD, Zon LI, Schlaeger TM, Lai LP, McMahon AP, Craft AM, Galloway JL. [A conserved transcription factor regulatory program promotes tendon fate.](https://pubmed.ncbi.nlm.nih.gov/39216481/) Developmental cell. 2024;59(23):3106–3123.e12. PMID: 39216481 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S1534580724004891?via%3Dihub) Tendons, which transmit force from muscles to bones, are highly prone to injury. Understanding the mechanisms driving tendon fate would impact efforts to improve tendon healing, yet this knowledge is limited. To find direct regulators of tendon progenitor... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S1534580724004891?via%3Dihub) Kassu M, Zulauf KE, Ross JN, Kirby JE, Manetsch R. [Development of CGS-15943 Adjunctives for the Disruption of Plasmid Maintenance in Multidrug Resistant .](https://pubmed.ncbi.nlm.nih.gov/39741382/) ACS infectious diseases. 2024; PMID: 39741382 Kassu M, Zulauf KE, Ross JN, Kirby JE, Manetsch R. [Development of CGS-15943 Adjunctives for the Disruption of Plasmid Maintenance in Multidrug Resistant .](https://pubmed.ncbi.nlm.nih.gov/39741382/) ACS infectious diseases. 2024; PMID: 39741382 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00587) Carbapenemase producing (CPEs) represent a group of multidrug resistant pathogens for which few, if any, therapeutics options remain available. CPEs generally harbor plasmids that encode resistance to last resort carbapenems and many other antibiotics. We... - [ descriptionPublisher's Version](https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00587) Hammel F, Payne C, Marando V, Mazitschek R, Walker S. [Identification of a Polypeptide Inhibitor of -GlcNAc Transferase with Picomolar Affinity.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11440498/) Journal of the American Chemical Society. 2024;146(38):26320–26330. PMCID: PMC11440498 Hammel F, Payne C, Marando V, Mazitschek R, Walker S. [Identification of a Polypeptide Inhibitor of -GlcNAc Transferase with Picomolar Affinity.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11440498/) Journal of the American Chemical Society. 2024;146(38):26320–26330. PMCID: PMC11440498 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubs.acs.org/doi/10.1021/jacs.4c08656) -GlcNAc transferase (OGT) is an essential mammalian enzyme that binds thousands of different proteins, including substrates that it glycosylates and nonsubstrate interactors that regulate its biology. OGT also has one proteolytic substrate, the... - [ descriptionPublisher's Version](https://pubs.acs.org/doi/10.1021/jacs.4c08656) Petrova V, Snavely AR, Splaine J, Zhen S, Singh B, Pandey R, Chen K, Cheng A, Hermawan C, Barrett LB, Smith JA, Woolf CJ. [Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11335239/) Cellular and molecular life sciences : CMLS. 2024;81(1):315. PMCID: 11335239 Petrova V, Snavely AR, Splaine J, Zhen S, Singh B, Pandey R, Chen K, Cheng A, Hermawan C, Barrett LB, Smith JA, Woolf CJ. [Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11335239/) Cellular and molecular life sciences : CMLS. 2024;81(1):315. PMCID: 11335239 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://link.springer.com/article/10.1007/s00018-024-05340-x) Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cancer chemotherapy that can often limit treatment options for cancer patients or have life-long neurodegenerative consequences that reduce the patient's quality of life. CIPN... - [ descriptionPublisher's Version](https://link.springer.com/article/10.1007/s00018-024-05340-x) Shehadeh F, Felix L, Kalligeros M, Shehadeh A, Fuchs BB, Ausubel FM, Sotiriadis PP, Mylonakis E. [Machine learning-assisted high-throughput screening for Anti-MRSA compounds.](https://pubmed.ncbi.nlm.nih.gov/39058605/) IEEE/ACM transactions on computational biology and bioinformatics. 2024;PP. PMID: 39058605 Shehadeh F, Felix L, Kalligeros M, Shehadeh A, Fuchs BB, Ausubel FM, Sotiriadis PP, Mylonakis E. [Machine learning-assisted high-throughput screening for Anti-MRSA compounds.](https://pubmed.ncbi.nlm.nih.gov/39058605/) IEEE/ACM transactions on computational biology and bioinformatics. 2024;PP. PMID: 39058605 - add\_circle do\_not\_disturb\_on Abstract **BACKGROUND:** Antimicrobial resistance is a major public health threat, and new agents are needed. Computational approaches have been proposed to reduce the cost and time needed for compound screening. **AIMS:** A machine learning (ML) model was developed for... Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. [Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.](https://pubmed.ncbi.nlm.nih.gov/38815134/) JCI insight. 2024;9(13). PMID: 38815134 Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. [Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.](https://pubmed.ncbi.nlm.nih.gov/38815134/) JCI insight. 2024;9(13). PMID: 38815134 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://insight.jci.org/articles/view/174329) The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we comprehensively evaluated how physiological... - [ descriptionPublisher's Version](https://insight.jci.org/articles/view/174329) Elfawal M, Goetz E, Kim Y, Chen P, Savinov S, Barasa L, Thompson P, Aroian R. [High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites](https://pubmed.ncbi.nlm.nih.gov/39653369/). ACS Infect Dis. 2024;(Dec 9). PMID: 39653369 Elfawal M, Goetz E, Kim Y, Chen P, Savinov S, Barasa L, Thompson P, Aroian R. [High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites](https://pubmed.ncbi.nlm.nih.gov/39653369/). ACS Infect Dis. 2024;(Dec 9). PMID: 39653369 - [ descriptionPublisher's Version](https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00327) - [ descriptionPublisher's Version](https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00327) Fontana P, Du G, Zhang Y, Zhang H, Vora S, Hu J, Shi M, Tufan A, Healy L, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo H, Agudo J, Lieberman J, Wu H. [Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity](https://pubmed.ncbi.nlm.nih.gov/39243763/). Cell. 2024;187(22):6165–6181. PMID: 39243763 Fontana P, Du G, Zhang Y, Zhang H, Vora S, Hu J, Shi M, Tufan A, Healy L, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo H, Agudo J, Lieberman J, Wu H. [Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity](https://pubmed.ncbi.nlm.nih.gov/39243763/). Cell. 2024;187(22):6165–6181. PMID: 39243763 - [ descriptionPublisher's Version](https://www.cell.com/cell/abstract/S0092-8674(24)00898-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424008985%3Fshowall%3Dtrue) - [ descriptionPublisher's Version](https://www.cell.com/cell/abstract/S0092-8674(24)00898-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424008985%3Fshowall%3Dtrue) Saffari A, Brechmann B, Böger C, Saber W, Jumo H, Whye D, Wood D, Wahlster L, Alecu J, Ziegler M, Scheffold M, Winden K, Hubbs J, Buttermore E, Barrett, Borner G, Davies A, Ebrahimi-Fakhari D, Sahin M. [High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia](https://pubmed.ncbi.nlm.nih.gov/38233389/). Nat Commun. 2024;15(1):584. Saffari A, Brechmann B, Böger C, Saber W, Jumo H, Whye D, Wood D, Wahlster L, Alecu J, Ziegler M, Scheffold M, Winden K, Hubbs J, Buttermore E, Barrett, Borner G, Davies A, Ebrahimi-Fakhari D, Sahin M. [High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia](https://pubmed.ncbi.nlm.nih.gov/38233389/). Nat Commun. 2024;15(1):584. - [ descriptionPublisher's Version](https://www.nature.com/articles/s41467-023-44264-1) - [ descriptionPublisher's Version](https://www.nature.com/articles/s41467-023-44264-1) Issa H, Fléchon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial I, Kluza J, Manier S. [MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10952034/). iScience. 2024;27(4):109417. Issa H, Fléchon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial I, Kluza J, Manier S. [MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10952034/). iScience. 2024;27(4):109417. - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2589004224006382?via%3Dihub) - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2589004224006382?via%3Dihub) Deblais L, Drozd M, Kumar A, Antwi J, Fuchs J, Khupse R, Helmy Y, Rajashekara G. [Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of Campylobacter jejuni in chickens](https://pmc.ncbi.nlm.nih.gov/articles/PMC11061419/). Front. Microbiol. 2024;(16 April). PMCID: PMC11061419 Deblais L, Drozd M, Kumar A, Antwi J, Fuchs J, Khupse R, Helmy Y, Rajashekara G. [Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of Campylobacter jejuni in chickens](https://pmc.ncbi.nlm.nih.gov/articles/PMC11061419/). Front. Microbiol. 2024;(16 April). PMCID: PMC11061419 - [ descriptionPublisher's Version](https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1342573/full) - [ descriptionPublisher's Version](https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1342573/full) Soni D, Borriello F, Scott D, Feru F, DeLeon M, Brightman S, Cheng W, Melhem G, Smith J, Ramirez J, Barman S, Cameron M, Kelly A, Walker K, Nanishi E, vanHaren S, Phan T, Qi Y, Kinsey R, Raczy M, Ozonoff A, Pettengill M, Hubbell J, Fox C, Dowling D, Levy O. [From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221515/). Sci Adv. 2024;10(27):eadg3747. Soni D, Borriello F, Scott D, Feru F, DeLeon M, Brightman S, Cheng W, Melhem G, Smith J, Ramirez J, Barman S, Cameron M, Kelly A, Walker K, Nanishi E, vanHaren S, Phan T, Qi Y, Kinsey R, Raczy M, Ozonoff A, Pettengill M, Hubbell J, Fox C, Dowling D, Levy O. [From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221515/). Sci Adv. 2024;10(27):eadg3747. - [ descriptionPublisher's Version](https://www.science.org/doi/10.1126/sciadv.adg3747) - [ descriptionPublisher's Version](https://www.science.org/doi/10.1126/sciadv.adg3747) Shamsabadi M, Jia X. [A fluorescence polarization assay for high-throughput screening of inhibitors against HIV-1 Nef-mediated CD4 downregulation](https://pubmed.ncbi.nlm.nih.gov/38960038/). J Biol Chem. 2024;300(8):107528. Shamsabadi M, Jia X. [A fluorescence polarization assay for high-throughput screening of inhibitors against HIV-1 Nef-mediated CD4 downregulation](https://pubmed.ncbi.nlm.nih.gov/38960038/). J Biol Chem. 2024;300(8):107528. - [ descriptionPublisher's Version](https://www.jbc.org/article/S0021-9258(24)02029-5/fulltext) - [ descriptionPublisher's Version](https://www.jbc.org/article/S0021-9258(24)02029-5/fulltext) Chen Y, Chaudhari S, Harris D, Roberts C, Moscalu A, Mathur V, Zhao L, Tavakkoli, Devlin A, Sheu E. [A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery](https://pubmed.ncbi.nlm.nih.gov/39043190/). Cell Host Microbe. 2024;17. Chen Y, Chaudhari S, Harris D, Roberts C, Moscalu A, Mathur V, Zhao L, Tavakkoli, Devlin A, Sheu E. [A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery](https://pubmed.ncbi.nlm.nih.gov/39043190/). Cell Host Microbe. 2024;17. - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/abs/pii/S1931312824002324?via%3Dihub) - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/abs/pii/S1931312824002324?via%3Dihub) Do B, Hsu P, Vermeulen S, Wang Z, Hirz T, Abbott K, Aziz N, Replogle J, Bjelosevic S, Paolino J, Nelson S, Block S, Darnell A, Ferreira R, Zhang, Milosevic J, Schmidt D, Chidley C, Harris I, Weissman J, Pikman Y, Stegmaier K, Cheloufi S, Su X, Syke D, Vander-Heiden M. [Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress](https://pubmed.ncbi.nlm.nih.gov/38823395/). Dev Cell. 2024;May. Do B, Hsu P, Vermeulen S, Wang Z, Hirz T, Abbott K, Aziz N, Replogle J, Bjelosevic S, Paolino J, Nelson S, Block S, Darnell A, Ferreira R, Zhang, Milosevic J, Schmidt D, Chidley C, Harris I, Weissman J, Pikman Y, Stegmaier K, Cheloufi S, Su X, Syke D, Vander-Heiden M. [Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress](https://pubmed.ncbi.nlm.nih.gov/38823395/). Dev Cell. 2024;May. - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/abs/pii/S1534580724003277) - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/abs/pii/S1534580724003277) ### 2023 Yang K, Whitehouse R, Dawson S, Zhang L, Martin J, Johnson D, Paulo J, Gygi S, Yu. [Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input](https://pubmed.ncbi.nlm.nih.gov/38118439/). Cell Chem Biol. 2023;31:1–12. Yang K, Whitehouse R, Dawson S, Zhang L, Martin J, Johnson D, Paulo J, Gygi S, Yu. [Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input](https://pubmed.ncbi.nlm.nih.gov/38118439/). Cell Chem Biol. 2023;31:1–12. - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2451945623004294?via%3Dihub) - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2451945623004294?via%3Dihub) Abbott K, Ali A, Casalena D, Do B, Ferreira R, Cheah J, Soule C, Deik A, Kunchok T, Schmidt D, Renner S, Honeder S, Wu M, Chan S, Tseyang T, Stoltzfus A, Michel S, Greaves D, Hsu P, Ng C, Zhang C, Farsidjani A, Kent J, Madariaga M, Gramatikov M, Matheson N, Lewis C, Clish C, Rees M, Roth J, Griner L, Muir A, Auld D, Heiden M. [Screening in serum-derived medium reveals differential response to compounds targeting metabolism](https://pubmed.ncbi.nlm.nih.gov/37689063/). Cell Chem Biol. 2023;30(9):1156–1168. Abbott K, Ali A, Casalena D, Do B, Ferreira R, Cheah J, Soule C, Deik A, Kunchok T, Schmidt D, Renner S, Honeder S, Wu M, Chan S, Tseyang T, Stoltzfus A, Michel S, Greaves D, Hsu P, Ng C, Zhang C, Farsidjani A, Kent J, Madariaga M, Gramatikov M, Matheson N, Lewis C, Clish C, Rees M, Roth J, Griner L, Muir A, Auld D, Heiden M. [Screening in serum-derived medium reveals differential response to compounds targeting metabolism](https://pubmed.ncbi.nlm.nih.gov/37689063/). Cell Chem Biol. 2023;30(9):1156–1168. - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2451945623002799?via%3Dihub) - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2451945623002799?via%3Dihub) Tharmalingam N, Xu S, Felix L, Roy B, Xian M, Mylonakis E, Fuchs B. [Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase](/publications/gold-complex-compounds-inhibit-drug-resistant-staphylococcus-aureus-targeting). Front. Antibiot. 2023;2(21 August 2023). Tharmalingam N, Xu S, Felix L, Roy B, Xian M, Mylonakis E, Fuchs B. [Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase](/publications/gold-complex-compounds-inhibit-drug-resistant-staphylococcus-aureus-targeting). Front. Antibiot. 2023;2(21 August 2023). - [ descriptionPublisher's Version](https://www.frontiersin.org/articles/10.3389/frabi.2023.1179354/full) - [ descriptionPublisher's Version](https://www.frontiersin.org/articles/10.3389/frabi.2023.1179354/full) Park Y, Taguchi A, Baidin, Kahne D, Walker S. [A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW](https://pubmed.ncbi.nlm.nih.gov/37099323/). Angew Chem Int Ed Engl. 2023;62(25):e202301522. Park Y, Taguchi A, Baidin, Kahne D, Walker S. [A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW](https://pubmed.ncbi.nlm.nih.gov/37099323/). Angew Chem Int Ed Engl. 2023;62(25):e202301522. Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, deOpakua A, Park JC, Luebbers A, Chen Q, Beeler A, Blanco F, Garcia-Marcos M. [Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160980/). Proc Natl Acad Sci U S A. 2023;120(18):e2213140120. Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, deOpakua A, Park JC, Luebbers A, Chen Q, Beeler A, Blanco F, Garcia-Marcos M. [Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160980/). Proc Natl Acad Sci U S A. 2023;120(18):e2213140120. - [ descriptionPublisher's Version](https://www.pnas.org/doi/10.1073/pnas.2213140120) - [ descriptionPublisher's Version](https://www.pnas.org/doi/10.1073/pnas.2213140120) Chen, Lye M, Gorgulla C, Ficarro S, Cuny G, Scott D, Wu F, Rothlauf P, Wang, Fernandez R, Pesola J, Draga S, Marto J, Hogle J, Arthanari, Coen D. [A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691697/). PLoS Pathog. 2023;19(11):e1011781. Chen, Lye M, Gorgulla C, Ficarro S, Cuny G, Scott D, Wu F, Rothlauf P, Wang, Fernandez R, Pesola J, Draga S, Marto J, Hogle J, Arthanari, Coen D. [A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691697/). PLoS Pathog. 2023;19(11):e1011781. - [ descriptionPublisher's Version](https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011781) - [ descriptionPublisher's Version](https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011781) Ajay A, Chu P, Patel P, Deban C, Roychowdhury C, Heda R, Halawi A, Saad A, Younis N, Zhang, Jiang X, Nasr M, Hsiao LL, Lin G, Azzi J. [High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145398/). Pharmaceutics. 2023;15(4):1274. Ajay A, Chu P, Patel P, Deban C, Roychowdhury C, Heda R, Halawi A, Saad A, Younis N, Zhang, Jiang X, Nasr M, Hsiao LL, Lin G, Azzi J. [High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145398/). Pharmaceutics. 2023;15(4):1274. - [ descriptionPublisher's Version](https://www.mdpi.com/1999-4923/15/4/1274) - [ descriptionPublisher's Version](https://www.mdpi.com/1999-4923/15/4/1274) Nguyen L, Wei Z, Silva M, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore C, Stricker J, Hortman C, Young-Pearse T, Haggarty S, Krichevsky A. [Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663445/). Nat Commun. 2023;14(1):7575. Nguyen L, Wei Z, Silva M, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore C, Stricker J, Hortman C, Young-Pearse T, Haggarty S, Krichevsky A. [Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663445/). Nat Commun. 2023;14(1):7575. - [ descriptionPublisher's Version](https://www.nature.com/articles/s41467-023-43293-0) - [ descriptionPublisher's Version](https://www.nature.com/articles/s41467-023-43293-0) Ryan C, Brander D, Barr P, Tyekucheva S, Hackett L, Collins M, Fernandes S, Ren Y, Zhou Y, McDonough M, Walker H, McEwan M, Abramson J, Jacobsen E, LaCasce A, Fisher D, Brown J, Davids M. [A phase 1b study of ibrutinib in combination with obinutuzumab in patients with relapsed or refractory chronic lymphocytic leukemia](https://pubmed.ncbi.nlm.nih.gov/36717653/). Leukemia. 2023;(Jan 30). Ryan C, Brander D, Barr P, Tyekucheva S, Hackett L, Collins M, Fernandes S, Ren Y, Zhou Y, McDonough M, Walker H, McEwan M, Abramson J, Jacobsen E, LaCasce A, Fisher D, Brown J, Davids M. [A phase 1b study of ibrutinib in combination with obinutuzumab in patients with relapsed or refractory chronic lymphocytic leukemia](https://pubmed.ncbi.nlm.nih.gov/36717653/). Leukemia. 2023;(Jan 30). - [ descriptionPublisher's Version](https://www.nature.com/articles/s41375-023-01830-2) - [ descriptionPublisher's Version](https://www.nature.com/articles/s41375-023-01830-2) Mitchell D, Kuljanin M, Li J, VanVranken J, Bulloch N, Schweppe D, Huttlin E, Gygi S. [A proteome-wide atlas of drug mechanism of action](https://pubmed.ncbi.nlm.nih.gov/36593396/). Nat Biotechnol. 2023;41(6):845–857. Mitchell D, Kuljanin M, Li J, VanVranken J, Bulloch N, Schweppe D, Huttlin E, Gygi S. [A proteome-wide atlas of drug mechanism of action](https://pubmed.ncbi.nlm.nih.gov/36593396/). Nat Biotechnol. 2023;41(6):845–857. Chew K, Lee, Ozonoff A, Smith J, Levy O, Dowling D, Haren S. [A protocol for high-throughput screening for immunomodulatory compounds using human primary cells](https://pubmed.ncbi.nlm.nih.gov/37453068/). STAR Protoc. 2023;4(3):102405. Chew K, Lee, Ozonoff A, Smith J, Levy O, Dowling D, Haren S. [A protocol for high-throughput screening for immunomodulatory compounds using human primary cells](https://pubmed.ncbi.nlm.nih.gov/37453068/). STAR Protoc. 2023;4(3):102405. - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2666166723003726?via%3Dihub#bib1) - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2666166723003726?via%3Dihub#bib1) - Previous page chevron\_left - [1](?page=0 "Current page") - [2](?page=1 "Go to page 2") - [3](?page=2 "Go to page 3") - [4](?page=3 "Go to page 4") - [5](?page=4 "Go to page 5") - [6](?page=5 "Go to page 6") - [7](?page=6 "Go to page 7") - [8](?page=7 "Go to page 8") - [9](?page=8 "Go to page 9") - [ Last page 14 ](?page=13 "Go to last page") - [ Next page chevron\_right ](?page=1 "Go to next page")