Publications by Year: 2015

CRISPR and TALEN support - GEPG. Genome Engineering Production Group (GEPG) is an on-campus (HMS) resource for custom CRISPR sgRNA and TALE nuclease expression constructs. 2015;
LabAutoPedia. 2015;
Medicinal Chemistry Core. The Medicinal Chemistry Core at DFCI collaborates with investigators on the development of small molecule probes and lead therapeutics. 2015;
Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med 2015;21(5):457-66.
Radomska HS, Jernigan F, Nakayama S, Jorge SE, Sun L, Tenen DG, Kobayashi SS. A Cell-Based High-Throughput Screening for Inducers or Myeloid Differentiation. J Biomol Screen 2015;20(9):1150-9.
Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol 2015;11(4):292-8.
Wallace J, Bowlin NO, Mills DM, Saenkham P, Kwasny SM, Opperman T, Williams DJ, Rock CO, Bowlin TL, Moir DT. Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay. Antimicrob Agents Chemother 2015;59(9):5775-87.
Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Guttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. elF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015;6:7194.
Medvetz D, Sun Y, Li C, Khabibulin D, Balan M, Parkhitko A, Priolo C, Asara JM, Pal S, Yu J, Henske EP. High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting. Mol Cancer Res 2015;13(1):50-62.
Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R. High-throughput screening for modulators of cellular contractile force. Integr Biol (Camb). 2015;7(10):1318-24.
Pery E, Sheehy A, Nebane NM, Brazier AJ, Misra V, Rajendran KS, Buhrlage SJ, Mankowski M, Rasmussen L, White EL, Ptak RG, Gabuzda D. Identification of novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem 2015;290(16):10504-17.
Lin S, Gregory RI. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol 2015;12(8):792-800.
Pery E, Sheehy A, Nebane MN, Misra V, Mankowski M, Rasmussen L, White LE, Ptak RG, Gabuzda D. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. Virology. 2015;484:276-87.
Crowther GJ, Weller SM, Jones JC, Weaver T, Fan E, Voorhis WCV, Rosen H. The Bacterial Sec Pathway of Protein Export: Screening and Follow-Up. J Biomol Screen 2015;20(7):921-6.
Carocci M, Hinshaw SM, Rodgers MA, Villareal VA, Burri DJ, Pilankatta R, Maharaj NP, Gack MU, Stavale EJ, Warfield KL, Yang PL. The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication. Antimicrob Agents Chemother 2015;59(1):85-95.
Johnson BK, Colvin CJ, Needle DB, Medie MF, Champion PA, Abramovitch RB. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. Antimicrob Agents Chemother. 2015;59(8):4436-45.
Papageorgiou A, Rapley J, Mesirov JP, Tamayo P, Avruch J. A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation [Internet]. 2015; PLoS One Mar 19;10(3):e0116096.
Chiaraviglio L, Kirby JE. High-throughput intracellular antimicrobial susceptibility testing of Legionella pneumophila. Antimicrob Agents Chemother. 2015;59(12):7517-29.
Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E. Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. PLoS One 2015;10(6):e0127640.
Friedman AA, Amzallag A, Pruteanu-Malinici L, Baniya S, Cooper ZA, Piris A, Hargreaves L, Igras V, Frederick JT, Lawrence DP, Haber DA, Flaherty KT, Wargo JA, Ramaswamy S, Benes CH, Fisher DE. Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEFR/PDGFR Combination Treatment. PLoS One 2015;10(10):0140310.