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Small Molecule

2024
Issa HB, Fléchon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial IM, Kluza J, Manier S. MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma [Internet]. iScience 2024;27(4):109417. Publisher's Version
Saffari A, Brechmann B, Böger C, Saber WA, Jumo H, Whye D, Wood D, Wahlster L, Alecu JE, Ziegler M, Scheffold M, Winden K, Hubbs J, Buttermore ED, Barrett L, Borner GHH, Davies AK, Ebrahimi-Fakhari D, Sahin M. High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia [Internet]. Nat Commun 2024;15(1):584. Publisher's Version
2023
Nguyen LD, Wei Z, Silva MC, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM. Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing [Internet]. Nat Commun 2023;14(1):7575. Publisher's Version
Chen H, Lye MF, Gorgulla C, Ficarro SB, Cuny GD, Scott DA, Wu F, Rothlauf PW, Wang X, Fernandez R, Pesola JM, Draga S, Marto JA, Hogle JM, Arthanari H, Coen DM. A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex [Internet]. PLoS Pathog 2023;19(11):e1011781. Publisher's Version
PubChem URL Data from this screen has been deposited in PubChem Bioassay. AID #1918969
Tharmalingam N, Xu S, Felix LO, Roy B, Xian M, Mylonakis E, Fuchs BB. Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase [Internet]. Front. Antibiot 2023;2(21 August 2023) Publisher's Version
Yang K, Whitehouse RL, Dawson SL, Zhang L, Martin JG, Johnson DS, Paulo JA, Gygi SP, Yu Q. Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input [Internet]. Cell Chem Biol 2023;31:1-12. Publisher's Version
Lin L, Chen D-Y, Scartelli C, Xie H, Merrill-Skoloff G, Yang M, Sun L, Saeed M, Flaumenhaft R. Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication [Internet]. iScience 2023;26(9):107602. Publisher's Version
Yadav PS, Papaioannou G, Kobelski MM, Demay MB. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes [Internet]. iScience 2023;26(9):107548. Publisher's Version
Potter DS, Du R, Bohl SR, Chow K-H, Ligon KL, Bueno R, Letai A. Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma [Internet]. Nat Commun 2023;14(2897) Publisher's Version
Kurmi K, Liang D, vandeVen R, Georgiev P, Gassaway BM, Han SJ, Notarangelo G, Harris IS, Yao C-H, Park JS, Hu S-H, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC. Metabolic modulation of mitochondrial mass during CD4+ T cell activation [Internet]. Cell Chem Biol 2023;30(9):1064-1075. Publisher's Version
Mitchell DC, Kuljanin M, Li J, VanVranken JG, Bulloch N, Schweppe DK, Huttlin EL, Gygi SP. A proteome-wide atlas of drug mechanism of action. Nat Biotechnol 2023;41(6):845-857.
Ajay AK, Chu P, Patel P, Deban C, Roychowdhury C, Heda R, Halawi A, Saad A, Younis N, Zhang H, Jiang X, Nasr M, Hsiao L-L, Lin G, Azzi JR. High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma [Internet]. Pharmaceutics 2023;15(4):1274. Publisher's Version
Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, deOpakua AI, Park J-C, Luebbers A, Chen Q, Beeler A, Blanco FJ, Garcia-Marcos M. Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer [Internet]. Proc Natl Acad Sci U S A 2023;120(18):e2213140120. Publisher's Version
Park Y, Taguchi A, Baidin V, Kahne D, Walker S. A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW. Angew Chem Int Ed Engl 2023;62(25):e202301522.
Abbott KL, Ali A, Casalena D, Do BT, Ferreira R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, Renner S, Honeder SE, Wu M, Chan SH, Tseyang T, Stoltzfus AT, Michel SLJ, Greaves D, Hsu PP, Ng CW, Zhang CJ, Farsidjani A, Kent JR, Madariaga MLL, Gramatikov MT, Matheson NJ, Lewis CA, Clish CB, Rees MG, Roth JA, Griner LM, Muir A, Auld DS, Heiden MGVander. Screening in serum-derived medium reveals differential response to compounds targeting metabolism [Internet]. Cell Chem Biol 2023;30(9):1156-1168. Publisher's Version
Sadeeshkumar H, Balaji A, Sutherland AG, Mootien S, Anthony KG, Breaker RR. Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch [Internet]. Anal Biochem 2023;666:115047. Publisher's Version
Sabag-Daigle A, Boulanger EF, Thirugnanasambantham P, Law JD, Bogard AJ, Behrman EJ, Gopalan V, Ahmer BMM. Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay [Internet]. Microbiol Spectr 2023;11(2):e0460622. Publisher's Version
Quek RT, Hardy KS, Walker SG, Nguyen DT, Magalhães TA, Salic A, Gopalakrishnan SM, Silver PA, Mitchison TJ. Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity. ACS Chem Biol 2023;18(3):583-594.
Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai L-H. A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation. J Exp Med 2023;220(11):e20222105.
Yang J-H, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA. Chemically induced reprogramming to reverse cellular aging [Internet]. 2023;15(13):5966-5989. Publisher's Version

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