# Publications ### Acknowledgement of ICCB-L in Publications Researchers using the services of ICCB-L staff or equipment agree to acknowledge the support of 'ICCB-Longwood Screening Facility at Harvard Medical School' in publications arising from your use of the facility. If an ICCB-L member has made an important intellectual contribution to the project, as determined by generally accepted criteria for academic collaborations, then that person should be considered for authorship on the publication. If your project was supported by a grant that also directly supports the ICCB-L, please consult the ICCB-L Director regarding the appropriate grant citation. Please notify Jen Smith upon public release of your publication. 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[Helpful Hints to Manage Edge Effect of Cultured Cells for High Throughput Screening.](http://hwpi.harvard.edu/files/iccb/files/an_hintsedgeeffecthts.pdf?m=1465310603) Corning Application Note. Tanner. [Helpful Hints to Manage Edge Effect of Cultured Cells for High Throughput Screening.](http://hwpi.harvard.edu/files/iccb/files/an_hintsedgeeffecthts.pdf?m=1465310603) Corning Application Note. - [ picture\_as\_pdfan\_hintsedgeeffecthts.pdf](/sites/g/files/omnuum5406/files/iccb/files/an_hintsedgeeffecthts.pdf) - [ picture\_as\_pdfan\_hintsedgeeffecthts.pdf](/sites/g/files/omnuum5406/files/iccb/files/an_hintsedgeeffecthts.pdf) PerkinElmer. [AlphaLISA Assay Development Guide](http://hwpi.harvard.edu/files/iccb/files/alphalisa-assay-development-guide_onepage_rev4_oct08.pdf?m=1465410512). PerkinElmer. [AlphaLISA Assay Development Guide](http://hwpi.harvard.edu/files/iccb/files/alphalisa-assay-development-guide_onepage_rev4_oct08.pdf?m=1465410512). - [ descriptionPublisher's Version](http://hwpi.harvard.edu/files/iccb/files/alphalisa-assay-development-guide_onepage_rev4_oct08.pdf?m=1465410512) - [ picture\_as\_pdfAlphaLISA Assay Developme...](/sites/g/files/omnuum5406/files/iccb/files/alphalisa-assay-development-guide_onepage_rev4_oct08.pdf) - [ descriptionPublisher's Version](http://hwpi.harvard.edu/files/iccb/files/alphalisa-assay-development-guide_onepage_rev4_oct08.pdf?m=1465410512) - [ picture\_as\_pdfAlphaLISA Assay Developme...](/sites/g/files/omnuum5406/files/iccb/files/alphalisa-assay-development-guide_onepage_rev4_oct08.pdf) ### 2026 [Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation](/publication/mast-cell-specific-cyslt2-receptor-signaling-inhibits-cysteinyl-leukotriene-dependent-1). Cell Reports. Elsevier; 2026;45(1). [Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation](/publication/mast-cell-specific-cyslt2-receptor-signaling-inhibits-cysteinyl-leukotriene-dependent-1). Cell Reports. Elsevier; 2026;45(1). - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://doi.org/10.1016/j.celrep.2025.116758) Cysteinyl leukotrienes (cysLTs) promote type 2 inflammation (T2I) by signaling through the type 1 and 3 cysLT-specific G protein-coupled receptors (GPCRs) (CysLT1R and CysLT3R). The type 2 cysteinyl leukotriene receptor (CysLT2R) can either promote or... - [ descriptionPublisher's Version](https://doi.org/10.1016/j.celrep.2025.116758) Petrova V, Mills CE, Hug C, Cetinkaya-Fisgin A, Splaine J, Fouladzadeh S, Hakim S, Powell R, Zhen S, Chung M, Bradshaw GA, Deng T, Singec I, Wang Q, Kawaguchi R, Jonnagaddala H, Barrett LB, Smith JA, Kalocsay M, Gyori BM, Hoke A, Sorger PK, Woolf CJ. [A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy](/publication/human-ipsc-derived-sensory-neuron-platform-high-throughput-discovery-neuroprotectants). Cell Reports Medicine. Elsevier; 2026; Petrova V, Mills CE, Hug C, Cetinkaya-Fisgin A, Splaine J, Fouladzadeh S, Hakim S, Powell R, Zhen S, Chung M, Bradshaw GA, Deng T, Singec I, Wang Q, Kawaguchi R, Jonnagaddala H, Barrett LB, Smith JA, Kalocsay M, Gyori BM, Hoke A, Sorger PK, Woolf CJ. [A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy](/publication/human-ipsc-derived-sensory-neuron-platform-high-throughput-discovery-neuroprotectants). Cell Reports Medicine. Elsevier; 2026; - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://doi.org/10.1016/j.xcrm.2026.102787) Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of cancer treatment, yet the lack of predictive human models continues to hinder therapeutic progress. Here, we establish a scalable and reproducible model of... - [ descriptionPublisher's Version](https://doi.org/10.1016/j.xcrm.2026.102787) ### 2025 Li W, Sparks RP, Sun C, Yang Y, Pantano L, Kirchner R, Arghiani N, Weilheimer A, Toles BJ, Chen JY, Moran SP, Barrera V, Li Z, Zhou P, Brassil ML, Wrobel D, Sui SJH, Aspnes G, Schuler M, Smith J, Medoff BD, Zhou C, Boustany-Kari CM, Rippmann JF, Santos DM, Doerner JF, Mullen AC. [Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11873113/) Nature communications. 2025;16(1):2109. PMID: 40025044 Li W, Sparks RP, Sun C, Yang Y, Pantano L, Kirchner R, Arghiani N, Weilheimer A, Toles BJ, Chen JY, Moran SP, Barrera V, Li Z, Zhou P, Brassil ML, Wrobel D, Sui SJH, Aspnes G, Schuler M, Smith J, Medoff BD, Zhou C, Boustany-Kari CM, Rippmann JF, Santos DM, Doerner JF, Mullen AC. [Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11873113/) Nature communications. 2025;16(1):2109. PMID: 40025044 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.nature.com/articles/s41467-025-56900-z) Hepatic stellate cells (HSCs) are activated with chronic liver injury and transdifferentiate into myofibroblasts, which produce excessive extracellular matrices that form the fibrotic scar. While the progression of fibrosis is understood to be the cause... - [ descriptionPublisher's Version](https://www.nature.com/articles/s41467-025-56900-z) Chong SJF, Lu J, Valentin R, Lehmberg TZ, Eu JQ, Wang J, Zhu F, Kong LR, Fernandes SM, Zhang J, Herbaux C, Goh BC, Brown JR, Niemann CU, Huber W, Zenz T, Davids MS. [BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11874845/) Molecular cancer. 2025;24(1):62. PMID: 40025512 Chong SJF, Lu J, Valentin R, Lehmberg TZ, Eu JQ, Wang J, Zhu F, Kong LR, Fernandes SM, Zhang J, Herbaux C, Goh BC, Brown JR, Niemann CU, Huber W, Zenz T, Davids MS. [BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11874845/) Molecular cancer. 2025;24(1):62. PMID: 40025512 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://link.springer.com/article/10.1186/s12943-025-02260-7) **BACKGROUND:** Established genetic biomarkers in chronic lymphocytic leukemia (CLL) have been useful in predicting response to chemoimmunotherapy but are less predictive of response to targeted therapies. With several such targeted therapies now approved for... - [ descriptionPublisher's Version](https://link.springer.com/article/10.1186/s12943-025-02260-7) Bharath N, DiPietro E, Durfee O, Kycia I, Splaine J, Sethupathy P, Rogers MS, Vakili K. [A novel high-throughput screening platform to identify inhibitors of DNAJB1-PRKACA-driven transcriptional activity in fibrolamellar carcinoma.](https://pubmed.ncbi.nlm.nih.gov/39947627/) SLAS discovery : advancing life sciences R & D. 2025;32:100221. PMID: 39947627 Bharath N, DiPietro E, Durfee O, Kycia I, Splaine J, Sethupathy P, Rogers MS, Vakili K. [A novel high-throughput screening platform to identify inhibitors of DNAJB1-PRKACA-driven transcriptional activity in fibrolamellar carcinoma.](https://pubmed.ncbi.nlm.nih.gov/39947627/) SLAS discovery : advancing life sciences R & D. 2025;32:100221. PMID: 39947627 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000140) Fibrolamellar carcinoma (FLC) is a primary liver cancer with a poor prognosis, primarily due to the lack of effective chemotherapeutic options. The DNAJB1-PRKACA (DP) gene fusion is recognized as the key oncogenic driver in FLC. This fusion arises from a... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000140) Law JD, Gao Y, Kovvali S, Thirugnanasambantham P, Wysocki VH, Ahmer BMM, Gopalan V. [Identification of inhibitors of the Salmonella FraB deglycase, a drug target.](https://pubmed.ncbi.nlm.nih.gov/39945759/) FEBS open bio. 2025; PMID: 39945759 Law JD, Gao Y, Kovvali S, Thirugnanasambantham P, Wysocki VH, Ahmer BMM, Gopalan V. [Identification of inhibitors of the Salmonella FraB deglycase, a drug target.](https://pubmed.ncbi.nlm.nih.gov/39945759/) FEBS open bio. 2025; PMID: 39945759 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.70001) Nontyphoidal Salmonella is one of the most prevalent causes of human foodborne illnesses worldwide, with no narrow-spectrum antibiotics or vaccines available. Here, we seek to address this gap. During the host inflammatory response, Salmonella metabolizes... - [ descriptionPublisher's Version](https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.70001) Quek RT, Shirazinejad CR, Young CL, Hardy KS, Lim S, Elms PJ, McSwiggen DT, Mitchison TJ, Silver PA. [Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein.](https://pubmed.ncbi.nlm.nih.gov/39894078/) SLAS discovery : advancing life sciences R & D. 2025;31:100220. PMID: 39894078 Quek RT, Shirazinejad CR, Young CL, Hardy KS, Lim S, Elms PJ, McSwiggen DT, Mitchison TJ, Silver PA. [Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein.](https://pubmed.ncbi.nlm.nih.gov/39894078/) SLAS discovery : advancing life sciences R & D. 2025;31:100220. PMID: 39894078 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000139) Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2472555225000139) [Mechanism and Regulation of Stu2:Ndc80 Association](/publication/mechanism-and-regulation-stu2ndc80-association). [United States -- Utah]: The University of Utah; 2025. p. 179+. [Mechanism and Regulation of Stu2:Ndc80 Association](/publication/mechanism-and-regulation-stu2ndc80-association). [United States -- Utah]: The University of Utah; 2025. p. 179+. - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://search.proquest.com/dissertations-theses/mechanism-regulation-stu2-ndc80-association/docview/3248478316/se-2?accountid=11311) Proper chromosome segregation is essential for cell division, relying on the attachment of duplicated chromosomes to microtubules, which pull chromosomes to opposite poles during anaphase of cell division. The kinetochore is the protein complex that... - [ descriptionPublisher's Version](https://search.proquest.com/dissertations-theses/mechanism-regulation-stu2-ndc80-association/docview/3248478316/se-2?accountid=11311) [Recent advances in high-throughput screening methods for small molecule modulators in bacteria](/publication/recent-advances-high-throughput-screening-methods-small-molecule-modulators-bacteria). 2025;85:102571+. [Recent advances in high-throughput screening methods for small molecule modulators in bacteria](/publication/recent-advances-high-throughput-screening-methods-small-molecule-modulators-bacteria). 2025;85:102571+. - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S1367593125000031) Bacterial infections, especially those that are resistant to antibiotics, constitute an increasing threat to public health. Deeper understanding about the systems that govern resistant infections, followed by the design of new therapies is crucial to... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S1367593125000031) [Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen](/publication/mechanistic-and-epigenetic-partitioning-lamina-associated-chromatin-revealed-genome). 2025;:2025.08.13.670143+. [Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen](/publication/mechanistic-and-epigenetic-partitioning-lamina-associated-chromatin-revealed-genome). 2025;:2025.08.13.670143+. - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](http://biorxiv.org/content/early/2025/08/14/2025.08.13.670143.abstract) The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their importance, the mechanisms governing LAD positioning in... - [ descriptionPublisher's Version](http://biorxiv.org/content/early/2025/08/14/2025.08.13.670143.abstract) - Previous page chevron\_left - [1](?page=0 "Current page") - [2](?page=1 "Go to page 2") - [3](?page=2 "Go to page 3") - [ Last page 50 ](?page=49 "Go to last page") - [ Next page chevron\_right ](?page=1 "Go to next page")