#  LSP Optimal Kinase Library 1mM 

 



This is a collection of characterized kinase inhibitors purchased from a variety of vendors and provided to ICCB-Longwood by [HMS LSP](https://labsyspharm.org/). Each compound is plated at 1 mM and was plated in January 2021.

The LSP Optimal Kinase Library is designed to probe the kinome with the most selective compounds as well as small molecule drugs and compounds in clinical development. Extended annotation on the targets of these compounds and information on how these compounds relate to each other in phenotypic fingerprint, Target Affintiy Spectrum and structure is available via [www.smallmoleculesuite.org](https://labsyspharm.shinyapps.io/smallmoleculesuite/).

This library is designed to have two inhibitors that are non-similar in structure, but comparable in selectivity for each kinase as described in [PMCID:PMC6526536](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526536/). The advantage of having two structurally distinct compounds is that they are more likely to have orthogonal target affinity spectra (TAS) (i.e. different off-target affinities). This feature enables users with a way to check if an observed effect is likely due to on-target or off-target action of the molecule.

SortNumber of Compounds:

 192

Plate Numbers:

3966 (1 Plate)

Concentration Information:

1mM in DMSO





 ![Plate 3966](/sites/g/files/omnuum5406/files/iccb/files/plate_3966.png)

 

384-Well Plate Format