# Fees

A fee is charged for access to small molecule screening at ICCB-Longwood. This fee helps us to recover some of our operating costs. ICCB-Longwood screening fees (and associated Facilities and Administration fees) are revised annually based upon the Harvard Fiscal Year (July 1 – June 30). New fees are typically recalculated in September or October of each year. The fee structure is updated here on the ICCB-Longwood website as soon as it is available. All charges are based on the screening fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below apply to screening activities carried out in FY17 (July 1, 2016 – June 30, 2017). We anticipate these fees will be in effect until Fall 2017, at which time the FY18 fees should be calculated and available.

Note that fees charged for access to ICCB-Longwood do not include the cost of screening reagents and supplies. Funding for all screening reagents and supplies is provided by the screener.

### Fees for HMS Internal Quad Screens

 Screening Milestone Fees Screen set-up fee $4,319 Additional fee for screening up to 5,000 experimental wells$2,159 Additional fee for screening 5,001-10,000 experimental wells $1,800 Additional fee for screening 10,001-25,000 experimental wells$2,519 Additional fee for screening 25,001-50,000 experimental wells $3,599 Additional fee for screening 50,001-100,000 experimental wells$3,599 Fee for screening additional increments of 100,000 experimental wells $5,344 The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at$2.75 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

### Small Molecule Fees - HMS Affiliates and Non-Harvard Academic

 Screening Milestone Fees Corresponding F&A Screen set-up fee $4,319$1,014 Additional fee for screening up to 5,000 experimental wells $2,159$507 Additional fee for screening 5,001-10,000 experimental wells $1,800$423 Additional fee for screening 10,001-25,000 experimental wells $2,519$592 Additional fee for screening 25,001-50,000 experimental wells $3,599$845 Additional fee for screening 50,001-100,000 experimental wells $3,599$846 Fee for screening additional increments of 100,000 experimental wells $5,344$1,256

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of theexperimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $2.75 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability. ## Additional Information on Small Molecule Fees Fees will begin to be assessed once work is initiated at ICCB-Longwood. For screens originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and Non-Harvard screeners), the indicated F&A fee is added at each stage of the screening fee. During the screening process, the appropriate fees will be charged as additional compounds are screened. Note that the “fee for screening up to 5,000 experimental wells” covers screening of 5,000 experimental library wells in duplicate and not 5,000 wells total. For example, a HMS Quad-based investigator who screens 75,000 compounds in duplicate will be charged a total of$17,995. An HMS-Affiliate who screens 75,000 compounds in duplicate will be charged a total of $17,995 + the corresponding F&A of$4,227.

There is an off-site screening fee structure for those small molecule screens that must be performed off-site for technical reasons (e.g. biosafety restrictions, instrumentation required for assay readout). Note that approval by the ICCB-Longwood Director or Deputy Director is required to initiate this type of screen. The FY2017 rate is $870.97 for set-up,$116 for F&A and then $85 per 384-well plate of small molecules screened. In addition, any consumables used for compound transfer are charged to the investigator. The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the compounds screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at$2.75 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Interested investigators should contact Jennifer Smith for more details and/or to determine which rate applies to their screen. Non-academic investigators should contact Jennifer Smith for the current industry price structure.