Fees

A fee is charged for access to small molecule screening at ICCB-Longwood. This fee helps us to recover a portion of our operating costs. ICCB-Longwood screening fees (and associated Facilities and Administration fees) are revised annually based upon the Harvard Fiscal Year (July 1 – June 30). The fee structure is updated on the ICCB-Longwood website as soon as it is available. All charges are based on the screening fee at the time of service, not a previously provided estimate or price structure from a previous fiscal year.

Fees below represent the rates for FY24 (July 1, 2023 - June 30, 2024).

Note that fees charged for access to ICCB-Longwood do not include the cost of screening reagents and supplies. Funding for all screening reagents and supplies is provided by the screener.

Fees for HMS Internal Quad Screens

Screening Milestone
Fees 
Screen set-up fee $5,927
Additional fee for screening up to 5,000 experimental wells

$2,964

Additional fee for screening 5,001-10,000 experimental wells $2,470
Additional fee for screening 10,001-25,000 experimental wells $3,458
Additional fee for screening 25,001-50,000 experimental wells $4,939
Additional fee for screening 50,001-100,000 experimental wells $4,939
Fee for screening additional increments of 100,000 experimental wells $7,335

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Small Molecule Fees - HMS Affiliates and Non-Harvard Academic

Screening Milestone
Fees 
Corresponding F&A
Screen set-up fee
$5,927
$1,186
Additional fee for screening up to 5,000 experimental wells
$2,964
$593
Additional fee for screening 5,001-10,000 experimental wells
$2,470
$494
Additional fee for screening 10,001-25,000 experimental wells
$3,458
$692
Additional fee for screening 25,001-50,000 experimental wells
$4,939
$988
Additional fee for screening 50,001-100,000 experimental wells
$4,939
$988
Fee for screening additional increments of 100,000 experimental wells
$7,335
$1,467

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the experimental wells screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Additional Information on Small Molecule Fees

Fees will begin to be assessed once work is initiated at ICCB-Longwood. For screens originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and Non-Harvard screeners), the indicated F&A fee is added at each stage of the screening fee.

During the screening process, the appropriate fees will be charged as additional experimental wells are screened. Note that the “fee for screening up to 5,000 experimental wells” covers screening of 5,000 experimental library wells in duplicate for each screen and counter-screen (if included) and not 5,000 wells total. For example, a HMS Quad-based investigator who screens 75,000 compounds in duplicate will be charged a total of $24,697. An HMS-Affiliate who screens 75,000 compounds in duplicate will be charged a total of $24,697 + the corresponding F&A of $4,939.

There is an off-site screening fee structure for those small molecule screens that must be performed off-site for technical reasons (e.g. biosafety restrictions, instrumentation required for assay readout). Note that approval by ICCB-Longwood is required to initiate this type of screen. The FY24 rate is $1,238 for set-up, $248 for F&A and then $119 per 384-well plate of small molecules screened. In addition, any consumables used for compound transfer are charged to the investigator.

The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the compounds screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.

Interested investigators should contact Jennifer Smith for more details and/or to determine which rate applies to their screen. Non-academic investigators should contact Jennifer Smith for the current industry price structure.