Fees will begin to be assessed once work is initiated at ICCB-Longwood. For screens originating from non-HMS Quad investigator labs (this includes HMS Affiliates whose labs are not located on the HMS Quadrangle and Non-Harvard screeners), the indicated F&A fee is added at each stage of the screening fee.
During the screening process, the appropriate fees will be charged as additional experimental wells are screened. Note that the “fee for screening up to 5,000 experimental wells” covers screening of 5,000 experimental library wells in duplicate for each screen and counter-screen (if included) and not 5,000 wells total. For example, a HMS Quad-based investigator who screens 75,000 compounds in duplicate will be charged a total of $24,697. An HMS-Affiliate who screens 75,000 compounds in duplicate will be charged a total of $24,697 + the corresponding F&A of $4,939.
There is an off-site screening fee structure for those small molecule screens that must be performed off-site for technical reasons (e.g. biosafety restrictions, instrumentation required for assay readout). Note that approval by ICCB-Longwood is required to initiate this type of screen. The FY24 rate is $1,238 for set-up, $248 for F&A and then $119 per 384-well plate of small molecules screened. In addition, any consumables used for compound transfer are charged to the investigator.
The above fees includes a cherry pick of 1.5 uL of up to 0.3% of the compounds screened. Additional cherry picks at a volume of 1.5 uL/compound can be requested at $5 per compound. Exceeding the 0.3% requires written scientific justification and is subject to compound availability.
Interested investigators should contact Jennifer Smith for more details and/or to determine which rate applies to their screen. Non-academic investigators should contact Jennifer Smith for the current industry price structure.