| Number of extracts |
1,056 |
| Plate Numbers |
1961-1963
(3 Plates) |
| Concentration Information |
Dried extracts resuspended at
~15 mg/ml in DMSO |
| Plate Format |
384-well plate
Plates 1961-1963:
Column 23-24 (empty)
 Click plate image to enlarge
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This library was plated and added to the collection in February 2008. Production of this natural product extract library was funded by a National Cooperative Drug Discovery Group (NCDDG) grant from the NIH-NCI to the University of Utah, Harvard Medical School, and the University of British Columbia. The library contains partially purified extracts from endophytic fungi (fungi that live in higher plants) that grow in
Costa Rica. The fungi have been collected and assembled by the National Biodiversity Institute (INBio) in Costa Rica. Crude extracts from each organism were obtained and further fractionated to eliminate nuisance compounds, especially those of high molecular weight or high polarity. This library was assembled under the Harvard Medical School portion of the NCDDG grant.
Screening positives that have been confirmed by follow-up experiments on cherry picked samples can be further fractionated via a collaboration with the lab of Dr. Jon Clardy (Harvard Medical School). Please contact Caroline Shamu (caroline_shamu"AT"hms.harvard.edu) to arrange for purification of "hit" compounds from extract samples."
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