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EMD Kinase Inhibitor 1

This is a collection of kinase inhibitors purchased from EMD Biosciences in August 2010 and provided to ICCB-L by Dr. Nathanael Gray. This collection includes three libraries sold by EMD as InhibitorSelect 96-Well Protein Kinase Inhibitor I (cat #: 539744, 80 compounds), InhibitorSelect 96-Well Protein Kinase Inhibitor II (cat #: 539745, 80 compounds) and InhibitorSelect 96-Well Protein Kinase Inhibitor III (cat #: 539746, 84 compounds). More information on this library can be found on the EMD website.

Number of Compounds 244
Plate Numbers 3229 (1 Plate)
Concentration Information 3.3 mM in DMSO

384-well Plate Format

  • Plate 3229

These inhibitors are quite potent. We recommend that you screen this library at a 1:300 dilution (100 nl compound stock into 30 ul assay volume), as is standard for most screens. In addition, we advise you to simultaneously screen this library using a lower pin transfer volume into the same assay volume (e.g. 33 nl compound stock into 30 ul assay volume) so that each assay tests two concentrations of each inhibitor.

Note that from August 2010 to February 2011, this library (same plate numbers) was available for pin transfer in 10 mM stock concentration. For most assays, we found that this concentration was too high (when diluted 1:300 for screening). Thus, as of March 2011, this library is now available for pin transfer from a stock concentration of 3.3 mM.

This library requires permission before screening. ICCB-Longwood screeners interested in screening this library should contact Jennifer Smith for more details.